Correlation Analysis Of TREM1 Gene Polymorphism And Biomarker Of Alzheimer's Disease

Background:Triggering receptor expressed on myeloid cells-1(TREM1)has been identified as one of the most associated loci for Alzheimer's disease(AD).Recently,TREM1 variant rs2234246~A was reported to regulate TREM-1 protein and m RNA levels.However,the role of this variant in AD continuum was not specifically assessed.Objective:We explored the effect of TREM1 locus on AD specific biomarker(amyloid-?PET)to investigate the role of rs2234246 in AD pathogenesis.Methods:We calculated the association of TREM1 locus with amyloid deposition at baseline and follow-up in multiple linear models and mixed effect models respectively in 522 ADNI subjects.Then we analyzed the association of TREM1 with this marker in subregion in the AD process.Results:In the cross-sectional analyses,TREM1 locus rs2234246~A was associated with the level of mean standard uptake volume ratios(SUVR)(p=0.02)in the pooled sample.It was associated with amyloid deposition within subgroups(MCI:p=0.04;AD:p<0.001).The brain amyloidosis of TREM1 showed obvious changes in longitudinal study in all participants(p=0.04).Exploratory analyses within diagnostic groups revealed that MCI group reached significance(p=0.04),dementia group was associated with mean SUVR(p=0.001).Moreover,TREM1 rs2234246~A was detected to be related to A?deposition in frontal,cingulate and temporal cortex in AD group observably in both cross-sectional and longitudinal analysis.Conclusions:This study demonstrated an association of TREM1 with brain amyloidosis.Our findings implied that TREM1 is involved in AD by influencing A? neuropathology.