Correlation Between Plasma SCD26 And SCD30 Concentrations And Hashimoto's Thyroiditis

Objective: To study the relationship between sCD26 and sCD30 concentrations in plasma of Hashimoto's thyroiditis(HT)patients and related laboratory indicators,and to preliminary explore the role of sCD26 and sCD30 in plasma in the pathogenesis of HT.Methods: Thirty HT patients and 20 healthy controls were selected,and the concentrations of sCD26,sCD30,IFN-?,and IL-4 in plasma were measured by ELISA;thyroid function and TgAb and TMAb were measured simultaneously;the HT group and the control group were tested.Compare and analyze the correlation between the indicators.Results: 1.Comparison of thyroid function and TgAb,TMAb between HT group and control group: There was no significant difference in sex or age distribution between HT and control group.In addition,TT3 and TT4 levels were comparable in both groups.The levels of TSH,TgAb and TMAb in the HT group were significantly higher than those in the control group(P <0.05).The levels of TT3 and TT4 in the significant HT(SH)group were significantly lower than those in the non-significant HT(NSH)group(P <0.05),and the levels of TSH in the SH group were significantly higher than those in the NSH group(P <0.05).There were no significant differences in gender,age,TgAb,and TMAb between the two groups.2.Comparison of sCD26 and sCD30 in different HT subgroups: The plasma sCD26 concentration in SH group was significantly lower than that in NSH group and control group(P <0.05),but there was no statistical difference between NSH group and control group.The concentration of sCD30 in SH group was significantly higher thanthat in NSH group and control group(P <0.05),but there was no statistical difference between NSH group and control group.The ratio of sCD26 / sCD30 in SH group plasma was significantly lower than that in NSH group and control group(P <0.05),and there was no statistical difference between NSH group and control group.3.Correlation between sCD26 and sCD30 levels and clinical indicators of HT: there is no correlation between sCD26 concentration in plasma and thyroid function;sCD26 concentration in plasma is negatively correlated with TgAb(r =-0.473,P =0.008);sCD26 in plasma Concentration was negatively correlated with TMAb(r =-0.437,P = 0.016).There was no correlation between plasma sCD30 concentration and thyroid function and TgAb or TMAb(P> 0.05).There was no correlation between sCD26 / sCD30 concentration and thyroid function and TgAb or TMAb(P> 0.05).4.Changes of IFN-? and IL-4 levels in HT and its subgroups: The concentration of IFN-? in HT group was higher than that in control group,and the difference was statistically significant(P <0.05).The concentration of IL-4 in the HT group was lower than that in the control group,and the difference was statistically significant(P<0.05).The IFN-? / IL-4 in the HT group was higher than that in the control group,and the difference was statistically significant(P <0.05).The mean value of IFN-? in SH group was higher than that in NSH group,and the difference was statistically significant(P <0.05).The mean IL-4 in SH group was lower than that in NSH group,and the difference was statistically significant(P <0.05).IFN-? / IL-4 in SH group was higher than that in NSH group,and the difference was statistically significant(P<0.05).5.Correlation between sCD26 and sCD30 levels and T-cytokines IFN-?,IL-4: The concentration of sCD26 is negatively correlated with IFN-?,r =-0.522,P = 0.003;sCD26 concentration and IFN-? / IL-4 was negatively correlated,r =-0.548,P =0.002;there was no correlation between the concentration of sCD26 and IL-4(P>0.05).There was no correlation between the concentration of sCD30 and IL-4(P>0.05).There was no correlation between sCD30 concentration and IFN-?(P> 0.05).There was no correlation between sCD30 concentration and IFN-? / IL-4(P> 0.05).Conclusion: sCD26 in HT patients' plasma is negatively correlated with TgAb and TMAb,and the concentration of sCD26 in HT plasma is significantly reduced,indicating that sCD26 acts as a negative regulator in the autoimmune process.In addition,there was a negative correlation between sCD26 and IFN-?.Therefore,sCD26 and sCD30 may play an important role in the occurrence and development of HT.The specific mechanism may be to induce the activation of Th1 type cells to produce chemokines to affect the autoimmune state.