| Objective:analyzing the risk factors of type 2 diabetes mellitus with combined osteopenia and use the Mongolian medicine Erdun wurile to treat the combined osteopenia and observe its curative effect,to provide scientific basis for type 2 diabetes mellitus combined with bone mass reduction.Methods of study:Methods:from December 2018 to December 2019,patients diagnosed as T2DM in the Department of Endocrinology,Affiliated Hospital of Inner Mongolia University of nationalities were collected.All inpatients were tested with one minute osteoporosis risk test of International Osteoporosis Foundation(IOF).The results showed that the positive patients were tested with BMD.According to BMD,the patients were divided into two groups:type 2 diabetes group(T2DM group)and type 2 diabetes combined with osteopenia group.100 cases were collected from each group.60 patients were randomly selected from 100 patients in type 2 diabetes mellitus with osteopenia group,and further randomly divided into control group(30 cases)and Mongolian medicine treatment group(30 cases).All the participants in this study collected information and data after admission:name,age,gender(menopause recorded by female patients),course of disease,smoking history;height(CM),weight(kg),body mass index(BMI),blood pressure(BP)were measured by specially assigned personnel;fasting blood glucose(FPG),HbAlc,fins,TC,glycerin were measured Detection of TG,HDL-C,LDL-C,CA,P,urinary protein,UACR,parathyroid hormone?N-terminal os-teocalcin??-Crosslaps?25-hydroxylvitamin D?total N-terminalpropeptide of type I rocollagen bone markers and T2DM related complications.?60 patients with type 2 diabetes mellitus and osteopenia were randomly selected for drug treatment.In the control group,calcium carbonate D3 granules were used twice a day,once a bag/time,vitamin D drops 400 units/day,orally;in the Mongolian medicine treatment group,calcium carbonate D3 granules were given twice a day,once a bag/time,vitamin D drops 400 units/day,orally,combined with Erdun wurile(both sides):after lunch,15 granules were taken orally,21 days after continuous oral administration,one week was a cycle,three cycles were used.For the enrolled patients,Mongolian medical certification was carried out before treatment,and the Mongolian medical symptoms of each patient were recorded in detail.After three cycles of treatment,the symptoms of Mongolian medicine were observed again,HbAlc,BMD,bone markers,VD,PTH were reexamined,and the total effective rate of symptoms of Mongolian medicine was compared.The improvement of BMD,bone markers,VD,PTH and Mongolian medical symptoms before and after treatment were compared.Results:1)there were statistically significant differences in age,course of disease,BMI,gender,smoking history and other factors between the two groups(P ?0.05),among them,the age and course of disease in the group of type 2 diabetes mellitus with bone mass reduction were higher than that in the group of T2DM,BMI was lower than that in the group of T2DM;women were prone to high incidence.In diabetic patients with nephropathy,retinopathy and neuropathy,the incidence of osteopenia in type 2 diabetic patients was significantly increased(P ?0.001);FPG and HbAlc in type 2 diabetic patients with osteopenia were significantly higher than those in T2DM patients(P ?0.01,P ?0.05);fins and TG in T2DM patients were significantly higher than those in type 2 diabetic patients with osteopenia Yi(P ?0.01,P ?0.05);2)after the treatment of type 2 diabetes mellitus with bone mass reduction,the total effective rate of Mongolian medicine symptom improvement in the control group was 30%,the total effective rate of Mongolian medicine symptom improvement in the Mongolian medicine treatment group was 93.3%,the improvement of Mongolian medicine symptom in the Mongolian medicine treatment group was statistically significant(P ?0.05);before and after the treatment,the bone markers and VD in the control group and the Mongolian medicine treatment group were statistically significant(P ?0.05);There was no significant difference between PTH and PTH(P?0.05);there was no significant difference between the control group and Mongolian medicine treatment group before and after treatment(P? 0.05).Conclusion:the statistical analysis of the risk factors of type 2 diabetes mellitus with osteopenia shows that there are independent risk factors in age,gender,course of disease,smoking and drinking history,body mass index(BMI),hyperglycemia,HbAlc,complications of type 2 diabetes.After Mongolian medicine intervention,Mongolian Medicine symptoms of type 2 diabetes mellitus patients with bone mass reduction were significantly reduced;the application results of Erdun wurile were better than expected,without any adverse reactions and side effects.It's preliminarily believed that Zhen bao pliis is an effeective prescription for the type 2 diabetes mellitus with combined osteopenia?... |
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