| Objective: To observe the clinical effect of traditional jiangtang pills on senile type 2diabetes mellitus patients with the syndrome of qi-yin deficiency.Methods: According to the diagnostic criteria of qi and yin deficiency syndromes of Senile type 2 Diabetes Mellitus,72 cases of Senile type 2 Diabetes Mellitus with the Syndrome of Qi-Yin Deficiency in the inpatient department of the Department of Endocrinology of Yunnan Traditional Chinese Medicine Hospital and the Second Affiliated Hospital of Yunnan University of Traditional Chinese Medicine were selected from December 2018 to January 2020 As the test object,72 cases patients were randomly divided into two groups: 36 cases in the treatment group(Jiangtang pills combined with metformin hydrochloride enteric-coated tablets)and 36 cases in the control group(metformin hydrochloride enteric-coated tablets).Combined with basic treatment,treatment for 12 weeks,observe clinical indicators such as blood glucose,blood lipids,insulin resistance index,islet ?-cellfunction and other clinical indicators,TCM symptoms,and compare the changes of the two groups of data before and after treatment through statistical analysis.Results:1.In the control group,1 case was shed,and 35 cases were actually included.In the treatment group,2 cases were shed,and 34 cases were actually included.2.Comparison of blood glucose efficacy: In this clinical study,both groups can effectively reduce fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPBG),Glycosylated Hemoglobin(HbA1c),Fructosamine(FRA),The efficacy of thetreatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).3.Comparison of blood lipid efficacy: In this clinical study,after treatment,both groups can effectively reduce Cholesterol(TC),Triglyceride(TG),Low density lipoprotein(LDL-C),and High-density lipoprotein(HDL-C)Level,the difference between the groups was statistically significant(P<0.05),in which the treatment group TG efficacy was significantly higher than the control group,the difference was statistically significant(P<0.01).4.Comparison of body mass index(BMI)efficacy: In this clinical study,both groups can effectively reduce BMI after treatment.There is no significant difference in treatment effect between the two groups,and the difference is not statistically significant(P>0.05).5.Comparison of Homeastatic Model Assessment of Insulin Resistance index(HOMA-IR)efficacy : In this clinical study,both groups can effectively improve HOMA-IR after treatment.The therapeutic effect of the treatment group is better than the control group between the two groups,and the difference is statistically significant(P<0.05).6.Comparison of islet function related indexes efficacy: In this clinical study,both groups can effectively reduce the level of Islet Amyloid Polypeptide(IAPP)after treatment,the difference is statistically significant(P<0.01),and the treatment group can improve Homeastatic Model Assessment of ? cell Function(HOMA-?),reduce the level of Thioredoxin Interacting Protein(TXNIP),increase the expression of the B-cell lymphoma-2(Bcl-2),the difference is statistically significant(P<0.01),while the control group has no difference Statistical significance(P>0.05);comparison between groups,treatment group improved HOMA-?,decreased TXNIP and IAPP levels,increased Bcl-2expression were better than the control group,the differences were statistically significant(P<0.05).7.Clinical efficacy evaluation,Main symptom,secondary symptom,total curative effect of TCM syndrome three aspects,The total effective rate of the treatment group respectively was 91.18%,88.24% and 88.24%,while the total effective rate of the control group respectively was 57.14%,51.43% and 60.00%.Compared with the two groups after treatment,the total curative effect of main symptoms,secondary symptoms and TCM syndromes in the two groups was statistically significant(P < 0.01).8.In this clinical study,there are no significant adverse reactions occurred in the two groups.Conclusion: Jiangtang pill can effectively improve the TCM syndrome of qi-yin deficiency in senile diabetes patients,and at the same time,it can reduce glucose,improve lipid metabolism,insulin resistance,HOMA-?,and provide a further clinical basis for the treatment of senile diabetes patients,which is worth promoting. |
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