| Objective:This study was to observe and analyze the effect of Guanxindanshen dropping pill on patients with depression and anxiety after coronary interventionMethod:The case in this study is from the patient with depression and anxiety after coronary intervention who was hospitalized in the outpatient or ward of three cardiovascular departments of Xiyuan Hospital,Chinese Academy of traditional Chinese medicine from November 2017 to October 2018.The patients were divided into experimental group and control group according to random number table.The experimental group was treated with Guanxindanshen dropping pill on the basis of basic treatment,while the control group was treated with Guanxindanshen dropping pill simulation agent on the basis of basic treatment;the basic treatment was treated with conventional cardiovascular drugs according to the guidelines of American Heart Association for coronary heart disease;both groups were treated with 10 pills/time,3 times/day,for 3 months;the subjects were visited 3 times in baseline,the 4th and the 12th weeks of treatment,before,during and after treatment The patients' Health Questionnaire(PHQ-9),generalized anxiety disorder scale(GAD-7),Seattle angina pectoris scale(SAQ)were tested before and after treatment.SPSS 23.0 statistical software was used.Results:1.Baseline data included in the study A total of 38 patients with depression and anxiety were included in the study,19 in the experimental group and 19 in the control group.27 male patients accounted for 71.05%of the total,13 in the experimental group and 14 in the control group;11 female patients accounted for 28.95%of the total,6 in the experimental group and 5 in the control group.There were 2 young people,accounting for 5.26%of the total;19 middle-aged people,accounting for 50%of the total;17 young and old people,accounting for 44.74%of the total.There were 0 young people,9 middle-aged people and 10 young and old people in the experimental group,2 young people,10 middle-aged people and 7 young and old people in the control group.The average course of disease was(63.00±47.54)months in the experimental group and(53.63±51.61)months in the control group.36 cases were mental workers,accounting for 94.74%of the total;2 cases were manual workers,accounting for 5.26%of the total.2.PHQ-9 scaleAt the beginning of the study,there was no significant difference in the scores of PHQ-9 between the experimental group and the control group,f(1,18)=0.003,P=0.954;at the middle of the study,there was no significant difference in the scores of PHQ-9 between the experimental group and the control group,f(1.18)=0.079,P =0.782;at the end of the study,there was significant difference in the scores of PHQ-9 between the experimental group and the control group,f(1,18)=34.002,P<0.001,the patients in the two groups The effect of the experimental group was better than that of the control group.The difference of PHQ-9 between the beginning and the middle of the study in the experimental group was statistically significant(P.The difference of PHQ-9 scores between the middle and the end of the study was statistically significant(P<0.001),and the effect of 12 weeks after treatment was better than that of 4 weeks;the difference of PHQ-9 scores between the beginning and the end of the study was statistically significant(P<0.001),and the depressive state of the patients was significantly improved after 12 weeks of treatment.The difference of PHQ-9 score between the beginning and the end of the study in the control group was statistically significant(P<0.001),which improved the depressive state of the patients after 4 weeks of treatment;the difference of PHQ-9 score between the middle and the end of the study was statistically significant(P<0.001),and the effect of 12 weeks after treatment was better than that of 4 weeks;the difference of PHQ-9 score between the beginning and the end of the study was statistically significant(After 12 weeks of treatment,the depressive state of the patients improved significantly3.GAD-7 scaleAt the beginning of the study,there was no significant difference in GAD-7 scores between the experimental group and the control group,f(1,18)=0.010,P=0.920;at the middle of the study,there was a statistical difference in GAD-7 scores between the experimental group and the control group,f(1,18)=10.558,P=0.004<0.01,the experimental group was superior to the control group;at the end of the study,there was a statistical difference in GAD-7 scores between the experimental group and the control group,f(1,18)=62.559,P<0.001,the effect of the experimental group is better than that of the control group.The influence of time factor on GAD-7 score in the experimental group was statistically significant.The difference between the GAD-7 scores at the beginning and the middle of the study was statistically significant(P<0.001),and the patients' performance improved after 4 weeks of treatment.Anxiety state:the difference of GAD seat 7 score between the middle and late stage was statistically significant(P<0.001),12 weeks treatment was better than 4 weeks treatment,and the difference of GAD 7 score between the beginning and the end of the study was statistically significant(P<0.001);after 12 weeks treatment,the anxiety of patients was significantly improved.The influence of time factor on GAD-7 score of control group was statistically significant.There was significant difference between GAD seat 7 score and control group(P.Status:there was no significant difference in GAD-7 scores between the middle and the end of the study(P<0.001);there was significant difference in GAD-7 scores between the beginning and the end of the study(P<0.001).After 12 weeks,the patients' anxiety improved significantly.4.SAQ scaleAt the beginning of the study,there was no significant difference between the test group and the control group in the score of Seattle angina pectoris scale,f(1,18)=0.061,P=0.808;at the middle of the study,there was significant difference in the score of SAQ between the test group and the control group,f(1,18)=23.120,P<0.001,and the effect of the test group was better than that of the control group;at the end of the study,there was no significant difference in the score of Seattle angina pectoris scale between the test group and the control group F(1,18)=98.334,P<0.001.The effect of the test group is better than that of the control group.The influence of time factor on the score of Seattle Angina scale in the experimental group was statistically significant.The difference between the score of Seattle Angina scale in the experimental group at the beginning of the study and in the middle of the study was statistically significant(P The effect of 12 weeks treatment was better than that of 4 weeks treatment(P<0.001).The difference of Seattle Angina scale score between the beginning and the end of the study was statistically significant(P<0.001).After 12 weeks treatment,the quality of life and the state of body function of the patients were significantly improved.There was no significant effect of time factor on the score of Seattle Angina scale in the control group.Conclusions:1.Guanxindanshen dropping pill is effective in the treatment of depression and anxiety after coronary intervention,which can improve the depression and anxiety of patients.2.Guanxindanshen dropping pill can improve the quality of life and body function of patients with depression and anxiety after coronary intervention. |
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