| Objective:To evaluate the effect of chemotherapy on ovarian function in young patients with stage 1C ovarian cancer,and to study the protective effect of Gn RHa on ovarian reproductive and endocrine function in young women requiring chemotherapy through AMH changes.Methods:From January 2014 to December 2017 in henan province people's hospital of department of gynaecology malignant nest egg cancer patients in hospital,line keep unilateral accessories and uterine surgery by stages,select confirmed by postoperative pathological diagnosis of 40 patients with ovarian cancer ? C period,according to the patient and family to choose,choose only 20 patients with chemotherapy(epithelial ovarian cancer in 13,germ cell tumor 7 cases)as control group.Twenty patients with Gn RHa combined with chemotherapy(13 cases of epithelial ovarian cancer,7 cases of germ cell malignant tumor)were selected as the observation group.The average age of the control group was 29.15 years old,and the average age of the observation group was 29.75 years old.There was no statistical difference in age between the two groups.Serum FSH and AMH values were measured before chemotherapy,after complete chemotherapy,6 months after chemotherapy,and 12 months after chemotherapy.Menstrual disorders and amenorrhea were followed up in the 2 groups,and the protective value of their ovarian function and Gn RHa on the ovarian reserve function of patients during chemotherapy was evaluated.Results:All the patients in the 1.2 group successfully completed chemotherapy,and there were no serious surgery or chemotherapy complications during the observation.By the end of follow-up,no tumor recurrence was found in the postoperative review.Amenorrhea was found in all the observation group(20cases)during chemotherapy,while in the control group,amenorrhea was found in 4 cases,menstrual disorder in 10 cases and normal menstruation in 6 cases.12 months after the end of chemotherapy,1 patient in the observation group had menstrual disorder with normal rest.In the control group,1 case had amenorrhea,6 cases had menstrual cycle disorder,and 13 cases had normal menstruation.The incidence of abnormal menstruation in the study group(1/20)was significantly lower than that in the control group(7/20),and the chi-square test showed that the incidence of abnormal menstruation in the observation group was lower than that in the control group(P < 0.05).2.There was no significant difference in serum FSH before chemotherapy between the observation group and the control group(P > 0.05).By the end of 12 months after chemotherapy,the difference in serum FSH between the two groups was statistically significant(P < 0.05).3.There was no significant difference in AMH before chemotherapy between the observation group and the control group(P > 0.05).At the end of chemotherapy,the serum AMH value of the two groups decreased compared with that before chemotherapy.Chemotherapy after 12 months,two groups of serum AMH values are lower than before chemotherapy,statistically significant differences(P <0.05),chemotherapy after 12 months,two groups of serum AMH values are higher than at the end of chemotherapy,statistically significant difference(P < 0.05),the contrast between the two way chemotherapy after 12 months,the observation group serum AMH value higher than the control group,difference has statistical significance(P < 0.05).Conclusions:1.Chemotherapy can lead to the injury of ovarian function,which can be restored to a certain extent after chemotherapy;2.2.Gn RHa has a protective effect on the ovarian function of patients during chemotherapy,which is conducive to reducing premature ovarian failure and protecting the reproductive reserve function of patients' ovaries. |
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