Ralationship Between Ultrasound Features Of Breast Cancer And Axillary Non-sentinel Lymph Node Metastasis

Objective: To analyze the relationship between breast cancer ultrasound signs,clinicopathological features,and axillary non-sentinel lymph node metastasis(NSLN)and predict the risk factors of non-sentinel lymph node metastasis.Methods: A retrospective analysis of 86 cases of breast cancer admitted to Nanhua Hospital of Nanhua University and the First Affiliated Hospital of Nanhua University underwent preoperative breast and axillary ultrasonography and sentinel lymph node(SLN)pathology confirmed positive.They were divided into non-sentinel lymph node metastasis group(36 cases)and non-sentinel lymph node non-metastasis group(50 cases).Clinicopathologic data,primary breast cancer ultrasound results and axillary lymph node ultrasound results were collected.Firstly,chi-square test was performed for all parameters between groups,and multivariate analysis was performed for statistically significant parameters between groups using logistic regression model.The test level was P=0.05.Results: Univariate analysis showed tumor size(P <0.000),number of positive SLNs(P <0.000),ratio of positive SLNs to total sentinel lymphocytes(P = 0.003),and human epidermal growth factor receptor-2,(HER-2)(P =0.041),molecular typing(P = 0.034),irregular morphology of primary ultrasound(P = 0.010),ratio of length to length of axillary lymph nodes(P <0.000),and axillary ultrasound It showed that the distribution of suspicious lymph nodes(P <0.000)between non-sentinel lymph node metastasis group and non-sentinel lymph node non-metastasis group was statistically significant.There were no significant differences between the two groups in patient age,tumor location,pathological type,pathological grade,Estrogen Receptor(ER),Progesterone Receptor(PR),and Ki67.The patient's ultrasound characteristics included primary echo,attenuation of posterior echo,border,burr or crabfoot,and calcification.,Blood flow,aspect ratio,and BI-RADS classification were not significantly different between the two groups.Multivariate analysis showed that tumor size(P = 0.031),number of positive SLNs(P =0.040),and the number of positive SLNs accounted for the total number of sentinel lymphocytes.The proportion(P = 0.009)and axillary ultrasound showed suspicious lymph nodes(P = 0.005)were independent predictors of non-sentinel lymph node metastasis.Conclusions:(1)Ultrasound of axillary lymph nodes in breast cancer patients can assess the risk of non-sentinel lymph node metastasis.(2)Tumor size,the number of positive SLNs,and the ratio of the number of positive SLNs to the total number of SLNs are also independent predictors of non-sentinel lymph node metastasis in breast cancer.