Microstructural Changes Of White Matter In Obstructive Sleep Apnea Hypopnea Syndrome On Diffusion Tensor Imaging Study

Objective:To explore the value of Diffusion tensor imaging?DTI?technology in the white matter microstructural of children with Obstructive sleep apnea-hypopnea syndrome?OSAHS?.Materials and methods:Twenty-two children with OSAHS?13 males and 9 females?and 19 healthy volunteers with age and gender?10 males and 9 females?were selected for routine head MRI scans and DTI scans.We used tract-based spatial statistics?TBSS?analysis to compare the differences of DTI parameters between groups,namely,Fractional anisotropy?FA?,Radial diffusivity?RD?,Axial diffusivity?AD?and Mean diffusivity?MD?.Threshold-free cluster enhancement?TFCE?method was used to perform multiple comparisons and corrections on the statistical results.Observe the changes of DTI parameters in children with OSAHS and the normal control group to obtain the location of the different brain regions.Pearson correlation analysis was performed to extract the same positive FA/RD/AD values of brain regions with differences in OSAHS group and the main indicators of sleep breathing monitoring?PSG?.Result:1?In a comparison between OSAHS and control subjects,the vaules of FA were significantly reduced in bilateral cerebellum,bilateral cerebral peduncle,upper longitudinal bundle,lower longitudinal bundle,inferior frontal occipital bundle,bilateral internal capsule posterior limbs,corpus callosum knee and body,etc.2?In a comparison between OSAHS and control subjects,the vaules of RD were significantly increased in bilateral cerebellum,frontal parietal lobe,bilateral cerebral peduncle,bilateral posterior limb of internal capsule,the knee and pressure of corpus callosum,etc.3?In a comparison between OSAHS and control subjects,the vaules of AD were significantly reduced in bilateral cerebral peduncle,bilateral posterior limb of internal capsule,the knee of corpus callosum.4?Compared with the normal control group,the MD value of OSAHS patients was not statistically significant.5?Compared with the normal control group,the brain regions with the same positive FA/RD/AD values of OSAHS patients were:bilateral cerebral peduncle,bilateral posterior limb of internal capsule,the knee of corpus callosum.6?The FA/RD/AD values of OSAHS patients were compared with the DTI parameter values of the left and right sides of cerebral peduncle of the positive brain area:there was no statistically significant difference between the two groups of left and right DTI parameter values?P>0.05?.7?In the OSAHS group,the FA/RD/AD values of different brain regions were positively correlated with the main indicators of sleep breathing monitoring?PSG?:the FA value of the knee of corpus callosum was positively correlated with the lowest SaO₂?r=0.589,P=0.004?,The FA value of bilateral posterior limb of internal capsule was negatively correlated with AHI?r=-0.538,P=0.010?,and there was no significant linear correlation?P>0.05?.Conclusion:1?In this study,a multi-parameter study of DTI wasperformed on OSAHS patients based on spatial statistical analysis of cellulose tracers,and it was found that the FA,RD,and AD values of multiple brain areas changed,confirming that there is extensive damage to the white matter of OSAHS patients.2?The FA value of the knee of corpus callosum was positively correlated with the lowest SaO₂,and the FA value of bilateral posterior limb of internal capsule was negatively correlated with AHI.The change of the value of the value can reflect the severity of the OSAHS condition of the child to a certain extent.3?OSAHS imaging significant changes in white matter microstructure provide important information for guiding clinical treatment and prognosis.