The Relationship Between The Quality Of Life, Inflammatory Markers And Nutritional Risk In Patients With Digestive System Cancer

Background Digestive system cancer includes esophageal cancer,cardiac cancer,gastric cancer,liver cancer,pancreatic cancer,gallbladder cancer,colon cancer and rectal cancer,which is the most common type of cancer except lung cancer.Because the malignant tumor of digestive system directly affects the patient’s eating and appetite,it has a huge impact on the nutrition intake and absorption,and then affects the quality of life of patients.Inflammatory response is common in patients with malignant tumors,as well as in the process of anti-tumor treatment,which makes the inflammatory response of patients with malignant tumors significantly higher than that of ordinary people.However,it has not been reported whether some common clinical inflammatory indicators are related to the nutritional risk of patients.Objective To study the relationship between the quality of life,clinical inflammation and nutritional risk in patients with digestive system cancer.Methods 1.From September 2017 to November 2019,101 patients with digestive system malignant tumor were selected from the oncology department of the First Affiliated Hospital of Xinxiang Medical College.The general clinical data of the patients were collected.According to nrs2002 score,the patients were divided into non nutritional risk group and nutritional risk group.The changes of quality of life and Blood Routine Indexes between the two groups were compared.Logistic regression analysis was used to screen the risk factors of nutritional risk in patients with digestive system cancer,and ROC curve was made to judge the test efficacy.In this study,2.28 patients admitted to hospital in November 2019 were selected,and about 5ml of peripheral blood samples were taken from the patients without treatment in this admission under fasting condition.Serum was separated and detected by using human interleukin-6(hereinafter referred to as IL-6)ELISA kit and human interleukin-8(hereinafter referred to as IL-8)ELISA kit of ibixin(Shanghai)Biotechnology corporation and double antibody sandwich enzyme-linked immunosorbent assay the content.Results 1.General clinical data:In this study,101 patients with digestive system cancer were included in the study,including 59 patients in the non nutrition risk group,31 males(52.54%),28 females(47.46%),with an average age of(60.59 ± 10.87);42 patients in the nutrition risk group,21 males(50%),21 females(50%),with an average age of(65.86 ± 9.89).The age of patients with nutritional risk and the proportion of patients who had received radiotherapy were higher than those without nutritional risk(P≤ 0.05);the weight,BMI,body function,role function,social function,overall quality of life,KPS score were lower than those without nutritional risk,the difference was statistically significant(P ≤ 0.05).There was no significant difference between the two groups in gender,tumor location,pathological type,clinical stage and the proportion of patients who had received chemotherapy(P > 0.05).2.Analysis of blood routine test results: The number of neutrophils,percentage of neutrophils and PLR of patients with nutritional risk were higher than those of patients without nutritional risk,the difference was statistically significant(P ≤ 0.05).There was no significant difference between the two groups(P > 0.05).3.Results of risk factor analysis: According to the analysis of clinical data and test indicators of the two groups,we further analyzed the indicators with statistical differences between the two groups,and used stepwise logistic regression to analyze the risk factors related to the nutritional risk of patients with digestive system tumors.The results showed that BMI,body function,KPS score and PLR were independent risk factors(P ≤ 0.05),among which BMI,KPS score and body function were protective factors and PLR were risk factors,all of them have good test efficiency.4.Comparison of serum IL-6 and IL-8: in 28 patients,compared with patients without nutritional risk,the expression of IL-6 in patients with nutritional risk was significantly increased,the difference was statistically significant(P ≤0.05),but the expression of IL-8 was no significant difference between the two groups(P > 0.05).Conclusion Nutritional risk makes the quality of life of patients with digestive system cancer significantly reduced.In addition,the clinical inflammatory indexes of patients with digestive system cancer with nutritional risk were significantly higher.And provide reference for further study on improving patients’ quality of life and inflammatory response in vivo.