Effect Observation Of Shenfu Injection On Non-cardiac Acute Ischemic Stroke And Clinical Study On Its Effect In Hypersensitive C-reactive Protein And Cystatin C

Objective To observe the clinical efficacy of Shenfu injection in the treatment of non-cardiac acute ischemic stroke and its effect on serum high-sensitivity C-reactive protein(hs-CRP)and cystatin C(Cys C).Methods From January 2018 to February 2019,130 hospitalized patients,those with acute noncardiac stroke,were divided into two groups according to the random number table.Including control group(68 cases)and experimental group(62 cases).The control group was given routine treatment in hospital,including taking aspirin and other antiplatelet aggregation,statins to reduce blood lipid,maintain electrolyte and acid-base balance.When severe brain edema and intracranial pressure increase,mannitol was given to reduce brain edema and intracranial pressure.The treatment of the experimental group is based on the treatment of the control group,giving Shenfu injection once a day intravenous drip,Shenfu Injection 100 ml per day,the treatment time is 2 weeks.At the end of 90 days after treatment,professional neurologists and patients face-to-face or by phone to understand the current status of patients,using MRS score to evaluate the improvement or deterioration of neurological function.At the same time,correlation analysis was carried out between hs-CRP,Cys C and NIHSS.The levels of serum hs-CRP,Cys C,NIHSS score,Barthel index,TCM syndrome score and modified Rankin revised scale(m RS)score before and after treatment were compared between the two groups.Data were analyzed by SPSS19.Results 1)Observation of curative effect: The NIHSS score,Barthel index score,TCM syndrome score and m RS score improved significantly in the experimental group(P < 0.05);2)Impact on biochemical indicators.Comparing the changes of hs-CRP and Cys C in the two group before and after treatment,it was found that the levels of hs-CRP and Cys C in the serum of the experimental group were significantly lower than those in the control group(P < 0.05);3)Correlation between hs-CRP,Cys C and NIHSS scores in 130 patients: hs-CRP and Cys C were positively correlated with NIHSS scores(R values were 0.642 and 0.315,respectively);Conclusion 1)Shenfu injection can significantly improve neurological deficits,TCM syndrome scores and clinical prognosis in patients with non-cardiac acute ischemic stroke;2)Shenfu injection can reduce serum hs-CRP and Cys C levels.3)Serum hs-CRP and Cys C levels in patients with non-cardiac acute ischemic stroke are positively correlated with the severity of their neurological deficits;...