Correlation Analysis Of Type 2 Diabetic Nephropathy With Blood Glucose Fluctuation And Oxidative Stress

Objective: To investigate the correlation between type 2 diabetic kidney disease and abnormal fluctuation of blood glucose and oxidative stress.Methods:A total of 90 patients with type 2 diabetes who were admitted to our hospital from January 2015 to December2017 were selected.According to the 24-hour UAlb,they were divided into the normal ualmin group(43 cases)and the high ualmin group(47 cases).General clinical data,blood glucose,blood lipid and other biochemical indicators of patients in the 2 groups were recorded,and the level of oxidative stress index superoxide dismutase(SOD)and malondialdehyde(MDA)was detected.The seven-stage self-monitoring of blood glucose was improved,and the standard deviation of blood glucose level(SDBG)was calculated.Results:The difference in the course of SDBG、SOD、MDA、UAlb between the two groups was statistically significant(P<0.05);Correlation analysis showed that UAlb was positively correlated with the course of disease,SDBG and MDA in patients with type 2diabetes(r=0.298,0.435,0.673,all P<0.05),while UAlb was negatively correlated with SOD(r=-0.716,P<0.05).SOD was negatively correlated with SDBG(r=-0.294,P<0.05),while MDA was positively correlated with SDBG(r=0.282,P < 0.05).Multiple linear regression analysis showed that SDBG and MDA were independent risk factors for diabetic nephropathy,while SOD was the protective factor.Conclusion:The course of diabetes,the fluctuation of blood glucose and the level of oxidative stress are correlated with the occurrence and development of diabetic nephropathy.