Effect Of Huazhi Pill On Intestinal Microecology In Patients With Primary Obesity Of Phlegm-dampness Type

Objective: to study the effects of Dr.Li yuxian,a national famous traditional Chinese medicine doctor,on body mass index(BMI),body fat rate(BFR),traditional Chinese medicine score and intestinal microecology in patients with primary obesity with phlegm and dampness.Methods: The principle of double-blind,randomization and placebo control was strictly implemented in this study.100 obese patients who met the inclusion criteria were randomly divided into the experimental group and the control group.Patients in both groups took the medicine under the guidance of healthy lifestyle.The experimental group was given a standard dose of 6g of hua zhi pills for 2times /d,while the control group was given a placebo for the same quality,color and properties.The experimental period was 12 weeks.Changes of subjects’ BMI,BFR,TCM syndrome score and intestinal microecology were observed and recorded before and after intervention.Results: 84 patients completed the experiment,including 43 in the huayin pill group and 41 in the placebo group.The comparison of BMI,BFR and TCM in obese patients before and after treatment showed statistically significant differences(P<0.05).There was no significant difference in BFR,P>0.05.Unqualified samples were removed from intestinal flora specimens.Finally,the abundance ratios of firmicutes,bacteroides and firmicutes/bacteroides in the intestinal tract of 60 patients were tested.There was no statistical difference in the difference of bacteroides abundance(P>0.05).The difference of firmicutes abundance ratio and firmicutes /bacteroidetes abundance ratio was statistically significant(P<0.05).Conclusion: huazhi pillseliminated BFRS in patients with obesity and bacteroidetes abundance less affected in the intestinal tract,there is no statistical difference,huazhi pill in patients with obesity BMI and thick wall bacteria in the gut and thick wall or door/bacteria-the bacteroidetes door abundance is significantly reduced,for the improvement of clinical symptoms were good,no obvious adverse reaction,better security,is worth further clinical promotion and application.