Retrospective Analysis Of 73 Cases Of Cochlear Implantation In Children

Objective: To investigate the deafness gene mutation in cochlear implant population,to compare the speech and hearing rehabilitation of patients with different gene mutations,and to give clinical guidance to patients with severe deafness.Methods: A total of 73 children who received cochlear implant(CI)in our hospital from January 2011 to May2019 were collected,including 41 males and 32 females,aged from 1.0 to 7.0 years old,with an average of 3.86 years old.DNA was extracted from venous blood to detect 9mutation hotspots of 4 common deafness genes in China by microarray chip method.According to the results of genetic screening,corresponding grouping was performed.Postoperative questionnaire surveys were Cotegories of auditory performance(CAP),Meaningful Auditory Integration Scale(MAIS),and Speech Intelligibility Rate(SIR)at1,3,and 6 months after the patient was switched on.Statistical analysis of MAIS,SIR,CAP before and after surgery.Results: Postoperative follow-up surveys were performed on the scores of MAIS,CAP,and SIR in each group of patients before surgery,1,3,and 6months after booting.It was found that there were significant differences in the results obtained at each time period(P<0.01).There was no significant difference among the experimental groups(P>0.05).Conclusion: Patients with bilateral severe-extremely severe sensorineural deafness who received CI implantation can achieve better speech hearing recovery after operation,and the recovery effect is positively correlated with the implantation time.Within 6 months after operation,there was little difference in the effect of speech hearing recovery among GJB2 group,SLC26A4 group and control group,which indicated that gene mutation had little effect on the effect of CI.