To Compare And Analyse ¹¹C-CHO And ¹⁸F-FDG PET-CT In The Diagnosis Of Single Lung Space Occupying Lesions

Objective:To study the diagnostic value and difference of ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG)and ¹¹C-choline(¹¹C-CHO)positron emission tomography/computed tomography?PET/CT?in single lung space occupying lesion.Methods:24 patients with lung space occupying were imaged with ¹⁸F-FDG and ¹¹C-CHO PET/CT respectively.The maximum standard uptake value?SUVmax?was calculated.SUVmax?2.5 was positive.The final diagnosis was based on pathological results or follow-up more than one year.The diagnostic value and consistency of the two methods were compared.The SUVmax and the ratio of tumor to non-tumor tissue?T/NT?of the two imaging agents in benign and malignant lesion were calculated and statistical analysis.Results:Among the 24 patients with pulmonary space occupying,13 cases of lung cancer and 11 cases of benign pulmonary lesion were diagnosed by pathological or clinical follow-up.17 cases were diagnosed by ¹⁸F-FDG PET/CT imaging and 21 cases were diagnosed by ¹¹C-CHO PET/CT.The accuracy?sensitivity and specificity of ¹⁸F-FDG PET/CT respectively was70.8%?84.6%?and 54.5%.The other was 87.5%?84.6%and 90.9%.The SUVmax and T/NT with malignant lesion were higher than those benign lesion in both ¹⁸F-FDG and¹¹C-CHO?P<0.05?,and the SUVmax and T/NT of ¹⁸F-FDG PET/CT in 13 patients with lung cancer were higher than ¹¹C-CHO?P<0.05?.In malignant pulmonary lesion,the SUVmax and T/NT in ¹¹C-CHO PET/CT increased with the increase of ¹⁸F-FDG,and showing a positive correlation?P<0.05?.Conclusion ¹¹C-CHO PET/CT imaging and¹⁸F-FDG PET/CT imaging have clinical value in diagnosis of lung occupying and they have moderat consistency.The SUVmax and T/NT of ¹⁸F-FDG PET/CT in lung cancer were higher than ¹¹C-CHO,and there was a positive correlation between them.But there was no correlation in benign lesion.