Cluster Analysis Of Autoantibody Profiles In 230 Patients With Lupus Erythematosus

Objective: The relationship between autoantibodies and clinical characteristics in patients with lupus erythematosus has been described and confirmed in a large number of essays.This paper aims to explore the clinical manifestations of different autoantibody clusters in patients with lupus erythematosus through cluster analysis.Methods: A total of230 patients with lupus erythematosus who were attended our hospital from February2018 to February 2019 were divided into the first diagnosis group(70 cases)and the subsequent visit group(160 cases),and cluster analysis was performed on 21 autoantibodies.The two groups of patients were divided into 3 clusters,and then the differences in various clinical manifestations between each group of each autoantibody cluster were compared.Results: 1.The first and subsequent visits were performed by a systematic clustering method.The first diagnosis group was classified into three clusters:1.1 group 1(11 cases),with anti-nRNP / Sm antibodies,anti-Ro-52 antibodies,anti-SS-A antibodies,1.2 anti-SS-B antibodies,Anti-dsDNA antibodies,anti-nucleosome antibodies,anti-ribosomal P protein antibodies,and anti-Sm antibodies were characterized by high positive rates,grouping 2(18 cases),1.3 with high positive rates of anti-histone antibodies For features.group 3(41 cases),composed of patients who did not belong to the first 2groups.2 The subsequent visit group was classified into three categories: 2.1 group 1(23cases),with high positives for anti-nRNP / Sm antibodies,anti-SS-A antibodies,and anti-Sm antibodies.2.2 The rate is characteristic,grouping 2(36 cases),with a high positive rate of anti-dsDNA antibodies,anti-nucleosome antibodies,anti-histone antibodies,anti-ribosomal P protein antibodies,perinuclear anti-neutrophil cytoplasmic antibodies feature.2.3 group 3(41 cases),composed of patients who did not belong to the first 2 groups.3 First visit group: 3.1 The levels of urinary protein and immunoglobulin G in group 1 were higher than those in the other two groups,and the levels of hemoglobin,C3,and C4 were lower than those in the other two groups,and the differences were statistically significant(P<0.05).3.2 The levels of aspartate transferase and alkaline phosphatase in group 3 were higher than those in the other two groups,and the difference was statistically significant(P<0.05).4 subsequent visit group: 4.1The levels of erythrocyte sedimentation rate,direct bilirubin,and immunoglobulin G in group 21 were higher than those in the other two groups,and the differences were statistically significant(P<0.05).4.2 The levels of c3 and c4 in group 2 were lower than those in the other two groups,and the difference was statistically significant(P<0.05).Conclusion: This study supports the existence of autoantibody clusters with unique clinical characteristics in systemic lupus erythematosus,and indicates that the formation of clinical subgroups based on autoantibody clusters may be useful for disease prediction and treatment evaluation.