The Expressions And Significance Of Caspase-1 And NLRP3 In Kimura's Disease

Objective: To investigate the expressions and significance of Caspase-1 and Nucleotide-binding domin-like receptor protein 3(NLRP3)in Kimura's disease(KD).Methods: the expressions of Caspase-1 and NLRP3 were immunohistochemically examined in 36 patients with KD and 10 normal controls.The integral absorbance(IA)of the two groups were compared.Meanwhile,clinical data was reviewed,the expression difference of caspase-1 and NLRP3 in each subgroup of clinical indicators were analyzed.Results: The IA of Caspase-1 [M(Q): 1765404(1912926)] and NLRP3 [M(Q): 2675401(2913750)] in KD were significantly higher than those in normal controls [M(Q): 130445(114688),151761(171231),P<0.05].The overexpression of both Caspase-1 and NLRP3 were significantly higher in the high-eosinophils group than those in the low-eosinophils(Z=-2.073,P<0.05;Z=-2.107,P<0.05).Moreover,NLRP3 was highly associated with disease recurrence(Z=-2.162,P<0.05).Associations of the expressions of Caspase-1 and NLRP3 were not found among age,gender,laterality,pruritus,maximum size of mass and multiplicity.Conclusions: Our result show that Caspase-1 and NLRP3 are closely related to the pathogenesis of Kimura's disease.Both Caspase-1 and NLRP3 are involved in the recruitment of eosinophils,while NLRP3 is related to the recurrence of Kimura disease.