Effects Of Dexmedetomidine On Expression Of TLR2 And TLR4 In Monocytes Of Blood During Perioperative Period In Patients Undergoing Pulmonary Lobectomy

ObjectiveTo evaluate the effects of dexmedetomidine on the expression of Toll-like receptor2?TLR2?and TLR4 in monocytes of blood during perioperative period in patients undergoing pulmonary lobectomy.MethodsFifty patients of both sexes,aged 40⁶4 yr,with body mass index of 20²4 kg/m²,of ASA physical status?or?,scheduled for elective pulmonary lobectomy under general anesthesia,were randomized into two groups?n=25 each?using a random number table:control group?group C?and dexmedetomidine group?group D?.In group D,dexmedeto-midine was infused intravenously at dose of 1.0?g/kg over 10 min before induction of anesthesia,followed by continuous infusion of at a rate of 0.3?g·kg^-1·h^-11 until 30 min before the end of operation,while the equal volume of normal saline was given in group C.After admission to the operating room,at 1.5h after beginning of operation,at the end of operation,and at 12 and 24 h after operation,blood samples were taken for blood gas analysis,and for determination of the expression of TLR2 and TLR4 in monocytes.Oxygenation index was calculated.The consumption of propofol and remifentanil and pulmonary complications within 48 h after operation were recorded.ResultsCompared with group C,the expression of TLR2 and TLR4 in monocytes of venous blood was significantly down-regulated,oxygenation index was increased,and the incidence of pulmonary complications after operation was decreased in group D?P<0.05?.ConclusionThe mechanism by which dexmedetomidine attenuates acute lung injury is associated with down-regulation of TLR2 and TLR4 expression in monocytes of blood in the patients undergoing pulmonary lobectomy.