| Objective:Accumulating evidence indicates that the N-a-terminal acetyltransferase 10(Naa10)plays a critical role in regulating various biological processes in various cancer,including colorectal cancer.However,the prognosis of patients and clinical significance of Naa10 in colorectal carcinogenesis remains largely unknown.In the present study,we aim to investigate the expression level of Naa10 in colorectal cancer tissues,and explore the relationship between its expression and clinical prognosis in these patients.Methods:In oncology department,collecting the colorectal cancer patients' clinical pathological datas,and its were operated colorectal cancer radical surgery and postoperative pathological diagnosis have been colorectal carcinogenesis,who hospitalized from January 1,2015 to December 31,2015 as the research object,and eventually include 110 cases that meet the requirements.According to the corresponding case number information,all the tumor tissue wax blocks and the corresponding normal tissue wax blocks were collected,and the wax blocks were sliced with a microtome to make white tablets fixed and dried.The expression of Naa10 in colorectal cancer tissues is detection by immunohistochemical analysis(HIC),according to resurts compare the clinicopathological features and prognosis of patients.Results:1.Naa10 expression levels in 110 cancerous and noncancerous tissues were examined by HIC.Naa10 levels in cancerous tissues were significantly higher than those in the noncancerous tissues(P<0.001).We divided the 110 patients with CRC into a high NaalO expression group(n=40)and a low expression group(n=70).The Kaplan-Meier survival curves revealed that patients in the high expression group had a significant poorer cilical prognosis than those in the low expression group,both for recurrence-free survival(RFS,log-rank test P=0.002)and overall survival(OS,log-rank test P=0.001).2.Respectively,the 3 years overall survival of between the high and low NaalO expression group were 65%and 90%.The patients in the high Naa10 expression group had a significantly poorer the 3 years overall survival than those in the low expression group(P=0.001).The 3 years recurrence-free survival of both the high and low Naa10 expression group were 65%and 90%,respectively.The patients in the high NaalO expression group had a significantly poorer the 3 years recurrence-free survival than those in the low expression group(P=0.009).3.Multivariate Cox regression analysis showed that high expression of NaalO gene was an independent risk indicator for pool prognosis in patients with colorectal cancer,and its was significantly associated with RFS and OS shortening in patients with colorectal cancer.recurrence-free survival(HR,2.361;95%CI,1.070-5.209;P=0.033)and overall survival(HR,3.040;95%CI,1.077-8.583;P=0.036).Conclusion:1.NaalO gene is highly expressed in colorectal cancer tissues,increased NaalO expression was signifcantly associated with lymph node metastasis,organ metastasis,vascular invasion,TNM stage and histologic differentiation.2.Patients with high expression of NaalO gene have significantly shorter 3-year RFS and 3-year OS expression,and patients with high expression of colorectal cancer have poor prognosis.3.Multivariate Cox analysis shows that NaalO gene High expression is associated with poor prognosis in patients with colorectal cancer and can be used as an independent risk factor for predicting the prognosis of patients with colorectal cancer. |
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