The Significance Of Preoperative Combined Detection Of Tumor Markers And Inflammatory Factors In Predicting The Prognosis Of Esophageal Squamous Cell Carcinoma

Objective The significance of preoperative combined detection of serum level of tumor markers and inflammatory factors in evaluating the prognosis of patients with esophageal squamous cell carcinoma was discussed.Methods Clinical data of 311 patients who underwent radical resection of esophageal cancer in the department of cardiothoracic surgery,general hospital of the eastern theater command from June 2014 to November 2016 were collected and followed up.Statistical software SPSS22.0 was used to analyze the data,(1)Explore the relationship between preoperative gender,age,BMI,tumor markers AFP,CEA,CA19-9,CA125,SCC,Cyfra21-1 serum levels,inflammatory factors,postoperative depth of invasion,lymph node metastasis,clinical TNM stage,maximum tumor diameter,Invasion of nerve vessels and postoperative survival prognosis of patients with esophageal squamous cell carcinoma;(2)Kaplan-meier method and single-factor ROC curve analysis were used to evaluate the ability of preoperative tumor markers,inflammatory factors and postoperative pathological indicators to evaluate postoperative prognosis of patients with esophageal squamous cell carcinoma;(3)Logistic and multivariate ROC curve analysis was used to evaluate the ability of preoperative combined detection of tumor markers and inflammatory factors to evaluate the postoperative prognosis of patients with esophageal squamous cell carcinoma.Results(1)Depth of invasion,lymph node metastasis,cell differentiation,clinical TNM stage,Invasion of nerve vessels and the maximum tumor diameter were related to the survival and prognosis of patients with esophageal squamous cell carcinoma(P<0.05).(2)The serum levels of preoperative tumor markers SCC and cycra21-1 were positively correlated with postoperative clinical TNM staging(P<0.05).(3)The inflammatory factors GPS,P-CRP,CPR were positively correlated with the depth of invasion T(P <0.05);LMR were negatively correlated with the depth of infiltration T(P <0.05).(4)Preoperative clinical indicators such as age,SCC,cyfra21-1,CRP,GPS,LMR,p-crp and CPR were all correlated with the survival and prognosis of patients with esophageal squamous cell carcinoma(P<0.05)(5)Age,SCC,CPR,cell differentiation,and TNM staging were independent risk factors for postoperative prognosis of patients with esophageal squamous cell carcinoma.(6)Preoperative combined detection of tumor markers and inflammatory factors(SCC + CYFRA21-1 + LMR + CPR)was better than a single index in predicting the prognosis of esophageal squamous cell carcinoma patients(0.697,P<0.001),,and slightly lower than TNM stage(0.731,P<0.001).Conclusions(1)Age,SCC,CPR,cell differentiation,and TNM staging were independent risk factors for postoperative prognosis of patients with esophageal squamous cell carcinoma.(2)Preoperative combined detection of tumor markers and inflammatory factors(SCC + CYFRA21-1 + LMR + CPR)was better than a single index in predicting the prognosis of esophageal squamous cell carcinoma patients,and slightly lower than TNM stage.