Clinical Significance Of Detection Of Cholesterol And Lymphocytes In Peripheral Blood Of Patients With Gastric Cancer And Its Correlation

Objective:Collect the total cholesterol(TC)and total lymphocytes(LYM)and pathological data in the peripheral blood of patients with gastric cancer before the first treatment,and explore the clinical significance of cholesterol and total lymphocyte count and whether there is a correlation between the two.Methods:The clinical and pathological data of 100 patients with gastric cancer who were first diagnosed and treated by the First Affiliated Hospital of Bengbu Medical College from January 2017 to January 2019 were retrospectively collected as the gastric cancer group.At the same time,the relevant data of 100 medical examinees who had no obvious abnormalities during the physical examination at the First Affiliated Hospital of Bengbu Medical College during the same period were selected as the control group.To analyze whether there are differences between the total cholesterol(cholesterol,TC)and total lymphocyte count(lymphocytes,LYM)in the peripheral blood of the two groups of subjects.At the same time,the number of peripheral blood cholesterol and lymphocytes in gastric cancer group before treatment were analyzed with the clinic pathological features such as infiltration degree,lymph node metastasis,distant metastasis,differentiation degree,TNM stage,age,sex,etc.meanwhile,to explore the correlation between them.Use receiver operating curve(ROC curve)to judge whether cholesterol and lymphocytes have diagnostic value for gastric cancer.To analyze whether there is correlation between cholesterol and lymphocytes in peripheral blood of patients with gastric cancer.Results:The level of cholesterol in peripheral blood of gastric cancer group was higher than that of control group(t=-2.447,P=0.016),and the level of lymphocyte was lower than that of control group(t=3.886,P=0.000),the differences were statistically significant.In the experimental group,cholesterol and lymphocytes were not statistically significant and had no significant correlation with gender,age,degree of infiltration,degree of differentiation,lymph node metastasis,distant metastasis and TNM stage(P>0.05),but cholesterol have a clear upward trend with the decrease of degree of differentiation and the increase of TNM stage;lymphocytes have a clear downward trend with the increase of TNM stage:People with low-to-medium differentiation have higher cholesterol than those with high differentiation,and those with stages III and IV have significantly higher cholesterol than those with stages I and II;those with stages III and IV have significantly lower lymphocytes than those with stages I and II.(Cholesterol(mmol/L):degree of differentiation:t=1.374,P=0.030;low-medium differentiation 4.41±1.02;high differentiation 4.02±0.89);TNM stage:t=-1.983,P=0.019;I+II stage 4.08±1.06;III+IV stage 4.44±0.95),(lymphocytes(10~9/L):TNM stage:t=1.531,P=0.021;I+II stage 1.84±0.62;III+IV stage 1.56±0.58).Cholesterol can be used as a diagnostic criterion for gastric cancer.The Area Under Curve(AUC)is 0.642,P=0.005,and its optimal threshold is4.06 which occurs when the sensitivity is 0.55 and the specificity is 0.74.At the same time,there was a significant positive correlation between cholesterol and lymphocytes in gastric cancer group(r=0.218,P=0.029).Conclusion:Abnormal cholesterol and lymphocytes can reflect the patient’s condition and nutrition and immune status in patients with gastric cancer.Cholesterol is a risk factor for gastric cancer.By interfering with the content of cholesterol,it can affect the immune status of the body and change its anti-tumor immunity.And provide new ideas and clinical basis for tumor immunotherapy.