Imaging Changes And Cognitive Function Of White Matter In People With Apnea Hypopnea Index Less Than 5

Objective: By observing the imaging of white matter in people with sleep apnea hypopnea index less than 5,and the changes of their cognitive function,to investigate whether people with AHI<5 have white matter changes and cognitive function decline,and possible factors lead to the change.Methods: 101 patients were involved in this research.Collecting their general data,various routine biochemical indicators,polysomnography(PSG),head MRI,and other neuropsychological cognitive function assessment(MOCA)of 49 patients.Divided into the following 5 groups according to different AHI intervals: 0?AHI<1,1?AHI<2,2?AHI< 3,3?AHI<4,4?AHI<5,the white matter was scored by the modified Scheltens scale,and AHI was compared with white matter and cognition by single factor analysis of variance There is a significant difference in the relationship of P <0.05.Results:1.All AHI groups,in the comparison of gender,age,BMI,hypertension,diabetes,smoking,drinking,maximum apnea time,minimum blood oxygen saturation,oxygen desaturation index,average blood oxygen,platelets,fasting blood glucose,triglycerides,total cholesterol,high-density lipoprotein,low-density lipoprotein,and homocysteine,the oxygen desaturation index in five group is higher than the first four groups,and the oxygen desaturation index is significantly different between groups(P<0.05),when AHI is between 4-5,there is a significant difference in the oxygen depletion index of the population(P<0.05).2.There was no significant difference in the deep white matter score,periventricular white matter score,and total white matter score between different AHI groups(P>0.05);3.Compare the cognitive function between different AHI groups,delayed recall scoring in five group is lower than the first four groups,delayed recall has significant differences between groups(P<0.05),and the other indicators have no significant differences between groups;4.Compare the delayed recall values of the AHI 0-4 group and the 4-5 group,the difference was statistical significant(P<0.05).Conclusion:1.The white matter changes in patients with AHI < 5 were not sensitive in conventional magnetic resonance examination.2.The oxygen desaturation index in AHI between 4-5 was significantly higher and delayed recall was impaired,which may require early intervention and treatment.