Incidence And Etiology Of Bacterial Infection In Decompensated Patients With Cirrhosis

Object:This study,by collecting complete clinical data of patients with decompensated cirrhosis complicated with bacterial infection,conducted a retrospective statistical analysis to explore the incidence of infection,etiological characteristics,drug resistance of common antimicrobial agents and the incidence of hospital-acquired and community-acquired infection in patients with decompensated cirrhosis,to provide experience and scientific basis for clinical selection of anti-infection treatment,and to hope to further improve the survival rate and reduce the mortality rate of patients with decompensated cirrhosis complicated with infection.Methods:The clinical data of 1612 patients with liver cirrhosis decompensated period admitted to the first people’s hospital of Chenzhou from March 2017 to March 2019 were collected,and 473 patients who met the diagnosis of infection and had complete clinical data were set up to organize the EXCEL table,and the case data database was formed for statistical analysis.Results:1.The bacterial infection incidence of patients with decompensated cirrhosis in our hospital was 29.34%(473/1612).2.The incidence of community-acquired infection was 67.7 per cent(320/473),the incidence of hospital-acquired infection was 32.3 per cent(153/473).3.Gram-negative bacilli accounted for 63.5%(80/126),Gram-positive bacteria was 33.3%(42/126),Escherichia coli was the main negative bacteria,accounting for 51.2%(41/80),Staphylococcus aureus was the main positive bacteria,accounting for 45.2%(19/42).4.Common gram-negative bacilli were not resistant to imipenem,meropenem,tegacycline and amikacin,and were highly resistant to ampicillin;Common gram-positive cocci were not resistant to vancomycin,tegacycline and linazolamide,and were highly resistant to clarithromycin;Escherichia coli,klebsiella pneumoniae and acinetobacter baumannii only had statistical differences in resistance to cefoxetine(P=0.013);Staphylococcus aureus and enterococcus faecium had no significant differences in resistance to common antimicrobial agents(P>0.05);There was no significant difference in the resistance of Escherichia coli and Staphylococcus aureus to various antimicrobial agents in hospital and community infection(P>0.05).Conclusion:1.An infection rate of 29.34% in patients with decompensated cirrhosis complicated with bacterial infection in our hospital,;The pathogens of infection is mainly Gram-negative bacilli.2.The incidence of community-acquired infections is significantly higher than that of hospital-acquired infections.3.Common gram-negative bacilli are not resistant to carbapenem,tegacycline and amikacin;Common gram-positive cocci are not resistant to vancomycin,tegacycline and linazolamide.4.The resistance of Enterobacter and Acinetobacter baumannii to cefoxetine was different,and there was no significant difference between Enterococcus faecium and Staphylococcus aureus in common antimicrobial resistance;There was no significant difference in resistance of hospital-infected and community-infected Escherichia coli and Staphylococcus aureus to common antimicrobial agents.