Value Of Tumor Fading Rate Of Induction Chemotherapy As An Early Biomarker Predictor Of Patient's Outcome In Locally Advance Nasopharyngeal Carcinoma

Objective:To explore whether the tumor fading rate after induction chemotherapy can be used to evaluate the prognosis of patients with locally advanced nasopharyngeal carcinoma.Methods:A retrospective analysis was performed on 220 patients with locally advanced nasopharyngeal carcinoma,histologically diagnosed,stage III-IVa,previously untreated ? All patients received 2 cycles induction chemotherapy,followed by concurrent chemoradiotherapy.We performed in all patients before and after induction chemotherapy of nasopharyngeal and neck imaging examination,and calculate the primary tumors and neck lymph nodes volume before and after induction chemotherapy,according to the(pre-GTV-post-GTV)÷ pre-GTV x 100% to calculate the percentage of tumor regression,and use SPSS 25.0 statistical software for data analysis,analyze the correlation with 5-year local recurrence-free survival(LRFS),distant metastasis-free survival(DMFS),disease progression-free survival(PFS),and overall survival(OS),respectively.Results:The primary tumor fading rate of patients after induced chemotherapy was significant associated with LRFS(P =0.022),DMFS(P=0.022),and was not correlated with PFS(P =0.378),OS(P =0.412),while thelymph node tumor fading rate was not correlated with LRFS(P =0.841),DMFS(P =0.841),PFS(P =0.727),and OS(P =0.596).The ROC characteristic curve analysis was used to calculate the optimal cut-off values of the primary tumor fading rate,LRFS,DMFS,PFS and OS,23.47%(AUC=67.5%),23.47%(AUC=67.5%),31.06%(AUC=52.9%)and 50.76%(AUC=67.5%),respectively.According to the optimal cut-off values divided the patients into tumor fading rate < optimal cutoff value vs tumor fading rate > optimal cutoff value,Kaplan-meier survival analysis for patients with 5-year LRFS(P <0.001),DMFS(P <0.001),and OS(P =0.027),while the primary tumor fading rate was not correlated with 5-year PFS(P =0.107).Conclusion:The volume regression rate of primary nasopharyngeal carcinoma was greater than 23.47%,23.47%,31.06% and 50.76%,and the5-year LRFS,DMFS,PFS and OS were significantly better than those less than the above regression rate?The lymph node tumor fading rate was not correlated with LRFS,DMFS,PFS and OS?...