Analysis Of Correlation Of Blood Lipid,abdominal Fat And Lumbar Spine Bone Mineral Density In Middle-aged And Elderly People Based On Quantitative CT

Objective: To analyze the correlation between blood lipids,abdominal fat and lumbar spine bone mineral density(BMD)in middle-aged and elderly people of different genders by measuring lumbar spine BMD and abdominal fat area using quantitative CT(QCT).Methods : Totally 680 subjects who underwent physical examinations were enrolled,including 345 males and 335 females,aged 40-88 years old,average age(53.33±9.77)years.And the height and weight were measured and their body mass index(BMI)was calculated.Fasting venous blood test for total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were performed.QCT was used to measure lumbar spine BMD and abdominal fat area,including total fat area(TFA),visceral fat area(VFA),and calculated the subcutaneous fat area(SFA).According to the lumbar spine measurements,the subjects were divided into normal bone mass group,bone mass reduction group and osteoporosis group for each gender,and the differences of lumbar spine BMD of3 groups for different genders and the correlation between lumbar spine BMDand various lipid parameters and abdominal fat area were analyzed.Taken lumbar spine BMD as the dependent variable,the parameters with statistically significant differences of male and female as independent variables,multiple linear regression analysis was performed.Results:1.Male BMI,TG,TFA and VFA were higher than females(all P<0.05),TC,HDL-C,LDL-C and SFA were smaller than females(P<0.05),There was no statistically significant difference in male and female age and lumbar spine BMD(P>0.05).2.In males,TC and LDL-C in the bone mass reduction group were higher than those in the normal bone mass group(both P<0.05),BMI in the osteoporosis group and the bone mass reduction group were lower than that in normal bone mass group(P<0.05),and SFA in osteoporosis group was lower than that in the reduced bone mass group and the normal bone mass group(P<0.05);In females,TC,LDL-C,TFA,VFA and SFA in the osteoporosis group and the bone mass reduction group were higher than that in normal bone mass group(all P<0.05).There was no significant difference in TG and HDL-C between the three groups of different genders(all P>0.05),There was no significant difference in TFA and VFA between the three groups of males(P>0.05),and no significant difference in the BMI between the three groups of females(P>0.05).3.Male lumbar spine BMD was negatively correlated with age,TG and HDL-C(all P<0.05),and positively correlated with BMI(P<0.05).Female lumbar spine BMD was negatively correlated with age,TC,TG,LDL-C,TFA,VFA and SFA(all P<0.05).4.Multiple linear regression results showed that age was a risk factor for the decline of lumbar spine BMD in middle-aged and elderly people,and VFA may be an important negative regulator for the decline of lumbar spine BMD infemale.Conclusion:1.Abnormal blood lipid metabolism and abdominal fat accumulation may be important factors inducing or exacerbating osteoporosis in the middle-aged and elderly population based on quantitative CT.2.Age is one of the risk factors leading to the decline of lumbar spine BMD in middle-aged and elderly people.3.Lumbar spine BMD in female is significantly negatively correlated with abdominal fat,of which intra-abdominal fat is an important regulating factor that determines the decline of lumbar spine BMD.