Drug-Coated Balloon Versus Plain Old Balloon For Superficial Femoralartery And Popliteal Artery Arteriosclerosis Obliterans And Analysis Of Influencing Factors

ObjectiveTo compare the efficacy and safety of paclitaxel drug-coated balloon(DCB)with Plain Old Balloon Angioplasty(POBA)in the treatment of arteriosclerosis obliterans and to analyze the related factors.MethodsA total of 86 patients admitted to the Fifth Affiliated Hospital of Zhengzhou University from June 2017to June 2018 were divided into DCB group(n=43)and POBA group(n=43)randomly.Males were 57 female were 29.with a average age of 65.3 ± 9.6.All of these patients are treated with endovascular interventional therapy.The patients were followed up for 6 to 14 months with an average follow-up time of(10.73±2.55)months.ankle brachial index(ABI),patency rate,the minimal lumen diameter and other related clinical indicators were observed in the follow-up period to evaluate the clinical efficacy.Influencing factors of restenosis were analyzed by using losgistic regression analysis and ROC curve.Results86 patients with vascular lesions were successfully opened.The success rate of Operation is 100%.Without vascular rupture,severe acute thrombosis of intraoperative complications,perioperative complications DCB group VS.POBA group(4.6%VS.7.0%)compared with no significant difference(P>0.05)A total of 19 stents were implanted,among which 10 cases DCB joint Silverhawk(3cases),POBA group of 9 cases of joint Silverhawk(2 cases),compared the two groups have no significant difference(P>0.05)There were no significant differences in the general situation,the characteristics of blood vessels and the surgical methods between the two groups(P>0.05).At 6 months and 12 months after treatment,patients in the drug-balloon group were superior to those in the POBA group(P<0.05)in terms of ABI,minimal lumen diameter,late lumen loss.There was no significant difference between the two groups in mortality,amputation rate and incidence of thrombosis(P>0.05).Hyperlipemia,smoking,length of the lesion,number of run off,and the use of drug-coated balloons were associated with restenosis.ConclusionThe drug-coated balloon was superior to the common balloon in the efficacy and safety of femoral artery arteriosclerosis obliterans.Hyperlipemia,smoking,long lesions and the situation of outflow channels were the important risk factors for postoperative restenosis.