Study On Brain Function Connection Of Refractory Facial Paralysis Based On ACC And Clinical Effect Observation Of Acupuncture Treatment

Purpose:(1)Compare the clinical scale scores of patients with refractory facial paralysis before and after treatment with those of ordinary peripheral facial paralysis,and explore the clinical efficacy of acupuncture for refractory facial paralysis,with a view to providing effective and effective diagnosis and treatment for the clinical treatment of the disease Program.(2)Using resting-state functional connectivity(rs FC)technology,using bilateral anterior cingulate gyrus(ACC)as the seed point(ROI),to observe acupuncture treatment of refractory facial paralysis and general peripheral facial paralysis Brain function connection changes before and after,to explore the possible brain regulation mechanism of acupuncture treatment of refractory facial paralysis.Method:(1)Twenty-two patients with refractory facial paralysis were included,and the HB(House-Brackmann)scale,FDIP,and FDIS(collectively referred to as the facial disability index scale)were collected before acupuncture treatment and after five weeks,respectively.Twenty-two patients with general peripheral facial paralysis were matched,and the HB scale was collected before acupuncture treatment and five weeks,and the data was analyzed by spass21.0 software for statistical analysis to evaluate the clinical efficacy of the two groups;(2)Two groups of patients collected two resting-state magnetic resonance data,and the time nodes of the two collections were before treatment and after one course of treatment,and bilateral ACC was used as ROI to process and analyze the whole brain magnetic resonance image.The differences in brain functional connections between patients with refractory facial paralysis and those with ordinary peripheral facial paralysis were compared.Result:(1)Comparing the refractory facial paralysis group with the general peripheral facial paralysis group,it was found that the difference between the two groups of HB scores after acupuncture treatment was statistically significant.Our results show that the general peripheral facial paralysis group has a higher efficiency,which indicates that acupuncture The degree of improvement in the clinical symptoms of facial paralysis is related to the course of disease.The later the acupuncture treatment is,the more difficult the treatment is,and the treatment effect is far less than that of the early treatment.The difference in the FDI score group before and after treatment in the refractory facial paralysis group is statistically significant,indicating that acupuncture It can improve the social function and physical function of patients with refractory facial paralysis,and improve the quality of social life of patients by improving the poor mood caused by facial paralysis.(2)Before acupuncture treatment,compared with the f MRI group of patients with refractory facial paralysis and patients with general peripheral facial paralysis,the brain areas with enhanced LACC and whole brain function are: left anterior cingulate gyrus,left posterior cingulate gyrus,and left temporal gyrus,Left angle gyrus,right middle temporal gyrus,right angle gyrus,left cerebellum,right cerebellum,left cerebellum(crus2);areas of the brain with weakened functional connections are: left marginal superior gyrus.The brain regions with enhanced RACC and whole brain function connections are: right orbital gyrus,right middle cingulate gyrus,right thalamus,right angle gyrus,right inferior temporal gyrus,left angle gyrus,left middle temporal gyrus,left cerebellum(IX),left Cerebellum(crus1),left fusiform gyrus.(3)After acupuncture treatment,compared with the f MRI group of patients with refractory facial paralysis and patients with general peripheral facial paralysis,the brain areas with enhanced LACC and whole brain function are: medial frontal gyrus,left anterior wedge,left cerebral island lobe,Left corner gyrus,right fusiform gyrus;brain regions with enhanced connection between RACC and whole brain function are:right posterior cingulate gyrus,right insular lobe,left corner gyrus,right corner gyrus,left middle temporal gyrus,left insular lobe,right The hippocampus turned back,the left tongue turned back.(4)Comparison of the fMRI group before and after acupuncture treatment in patients with refractory facial paralysis.The areas of the brain with enhanced LACC and whole brain connection are: the left parietal lobe;the areas of weakened functional connection are: the right cerebellar vermiform.There was no significant difference between RACC and whole brain connection.(5)Comparing the f MRI group before and after acupuncture treatment in patients with general peripheral facial paralysis,the brain areas with enhanced LACC and whole brain connection are: left medial temporal pole,left caudate nucleus,left central posterior gyrus;brain areas with weakened functional connections are: Left fusiform gyrus.There was no significant difference between RACC and whole brain connection.Conclusion:(1)Acupuncture can improve the clinical symptoms of patients with refractory facial paralysis or common peripheral facial paralysis,especially for general peripheral facial paralysis,indicating that the more timely and effective the acupuncture treatment is.(2)Anterior cingulate gyrus participates in the compensation mechanism of facial movement and emotional regulation in patients with refractory facial paralysis,which is closely related to the rehabilitation of patients with refractory facial paralysis.(3)Acupuncture treatment of refractory facial paralysis may regulate the limbic system,pre-exercise areas,and the default mode network to promote the reorganization of brain function,thereby improving facial movement and emotional regulation,improving patients' social and physical functions,and improving life quality.