Clinical Characteristics And Survival Status Of 41 Patients With Primary Diffuse Large B Cell Lymphoma Of Thyroid Gland

Objective:To explore the clinical manifestations,pathological features,diagnosis and treatment,and prognostic factors of 41 cases of primary thyroid diffuse large B-cell lymphoma(PTDLBCL),so as to provide a reference for the diagnosis and treatment of PTDLBCL.Methods: The clinical and medical records of 41 patients with PTDLBCL confirmed by pathologists in the Affiliated Tumor Hospital of Xinjiang Medical University from January 2010 to December 2018 were analyzed retrospectively.Statistical analysis was used to evaluate the clinical characteristics,survival analysis and prognostic factors of the disease.Results:Of all 41 patients,19 were Ann Arbor I to II and 22 were Ann Arbor III to IV.Among them,17 had Hashimoto's thyroiditis background.For all 41 patients,the 1-year,3-year and 5-year survival rates were 65.9%,39.0% and 22.0%,respectively.The results of univariate and multivariate analysis showed that the treatment mode was related to the prognosis(P=0.000),and the comprehensive treatment mode was more suitable for survival.But age,gender,tumor diameter,tumor stage,international prognosis index,LDH level,? 2-microglobulin,cell source and other factors had no significant difference in survival rate(P>0.05).Conclusion:PTDLBCL is more common in elderly women with Hashimoto's thyroiditis.The background of most thyroid lymphoma with Hashimoto's thyroiditis needs further study.Although the incidence rate of thyroid lymphoma is low,its pathological types are diverse.B cells are more common and the pathological type is mainly DLBCL.Combined therapy based on surgery,chemotherapy and radiotherapy can improve the survival rate of patients.