The Predictive Value Of Stroma Tumor-infiltrating Lymphocytes And PD-L1 In Patients With Triple Negative Breast Cancer Treated With Neoadjuvant Chemotherapy

Objective: To analyze the predictive value of stroma tumor-infiltrating lymphocyte(sTILs)and PD-L1 in patients with TNBC treated with neoadjuvant chemotherapy.Methods: We selected 42 female patients with TNBC diagnosed using core needle biopsy and treated with neoadjuvant chemotherapy and surgery.Evaluation of sTILs followed a standardised methodology for visual assessment on haematoxylin–eosin sections and immunohistochemistry was used to detect PD-L1 before and after NAC.The relation between sTILs,PD-L1 and clinical features and response to neoadjuvant chemotherapy were then analyzed.Results: 1.Neoadjuvant chemotherapy was effective in 83.3%(35/42)of the patients.2.Patients with PD-L1 negative and higher sTILs are more likely to achieve a better response to neoadjuvant chemotherapy.4.The sTILs fraction is correlated with histological grade and clinical stages.And the histological grade and lymph node metastasis were significantly correlated with the expression of PD-L1 in TNBC.Conclusion: STILs and PD-L1 can be used as independent indexes to predict the response to neoadjuvant chemotherapy in patients with TNBC.