The Correlation Analysis Between Epicardial Fat Volume,Body Mass Index And Carotid Atherosclerosis

Objective:The aim of the study was to analyse the relationship between epicardial adipose tissue volume,body mass index(BMI)and carotid atherosclerosis.The results of the study may provide new clinical reference index for prevention,treatment and rehabilitation of carotid atherosclerosis.At the same time,it can also provide the basis for predicting the occurrence of cardiovascular disease.Method:A total of 136 consecutive patients undergoing coronary computed tomogramphic angiography and carotid color ultrasonography in affiliated hospital of Taishan Medcial University were enrolled.99 cases were diagnosed as carotid artery atheroscl erosis by carotid color ultrasonography,and the other 37 patients were non carotid artery atherosclerosis.Patients’ gender,age,smoking history,history of hypertension,diabetes and other basic information were collected,besides,we also collected blood glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C),creatinine,blood urea nitrogen(BUN),β 2 microglobulin,uric acid and other indicators.In carotid color ultrasonography,we need record intima-media thickness,presence of plaques.For patients with carotid plaques we also need the size of plaque,and calculate the Crouse Score.In coronary CTA,Epicardial fat volume were measured.All indexes above were statistically analyzed.Results:General data analysis showed that,in carotid artery atherosclerosis group the age,systolic blood pressure,blood sugar,β2 microglobulin,IMT,EAT were significantly higher than indexes in non carotid atherosclerosis group(P<0.05).In patients with carotid atherosclerosis,epicardial fat volume were positively correlated with Crouse Score(r=0.308).Logistic regression analysis showed that age,systolic blood pressure,blood sugar and EAT volume were significantly associated with the occurrence and development of carotid artery atherosclerosis(P<0.05).ROC curve showed that epicardial fat volume has a certain accuracy in predicting carotid artery atherosclerosis,the best cut off point was 101.1 cm2(sensitivity 83.5%,Specificity 67.6%).In the carotid artery atherosclerosis group,BMI and EAT volume were relevanted(P < 0.05).Conclusion:Epicardial fat volume is closely related to carotid artery atherosclerosis,is an independent risk factors for carotid atherosclerosis.In patients with carotid atherosclerosis,Crouse Score and epicardial fat volume is positive correlated.In patients with carotid atherosclerosis,BMI is associated with Epicardial Adipose Tissue.