The Dosage And Efficacy Of Penehyclidine Hydrochloride In The Treatment Of Acute Organophosphorous Pesticide Poisoning

Objective:To investigate the dosage and efficacy of Penehyclidine Hydrochloride in the treatment of acute organophosphorus pesticide poisoning.Method:All 123 cases of AOPP were diagnosed by emergency and EICU in our hospital from January 1,2015 to December 31,2017.They were randomly divided into the standard dose group and the observation dose group,Both group were treated with penehyclidine hydrochloride and chloropodipine.According to light,middle,and severe degree of poisoning,the observation dose group was given the first dose of 0.5~1mg,1mg,1~2mg penehyclidine hydrochloride intramuscular injection,After penehyclidine hydrochloride etherification,0.5mg per 8 to 12 hours,1mg per 6 to 8 hours,1mg per 6 to 8 hours in maintenance therapy;the standerd dose group was given the first dose of 1~2mg,2~4mg,4~6mg penehyclidine hydrochloride intramuscular injection,After penehyclidine hydrochloride etherification,1~2mg per 8 to 12 hours in maintenance therapy.Both groups were given simultaneous treatment of pralidoxime chloride as early as possible.The medication status,symptom disappearance time,recovery of cholinesterase activity,ventilator boarding time,average hospitalization days and the occurrence of adverse reactions were observed in two groups.Result:There were no signification difference of the time of breathing and the time of hospitalization,the length of hospital stay,the time of symptom disappearance,the recovery of cholinesterase activity,the rebound time and the incidence of intermediate syndrome between two groups(P>0.05).Dosage for the first time,total dosage were less than that of the standerd group,differences are statistically significant(P<0.05);The incidences of delirium,the incidence rate of heartbeat tachycardia,high fever,penehyclidine hydrochloride dependence were lower than those of the standerd group,differences are statistically significant(P<0.05).Conclusion:The observation dose penehyclidine hydrochloride in the treatment of AOPP unchanged the efficacy,reduced adverse reations.