Predictive And Prognostic Roles Of ERCC1 In Patients With Pancreatic Cancer Treated With Platinum-based:A Meta-analysis

Objective:The expression of ERCC1 in pancreatic cancer patients treated with platinum-based chemotherapy and its prognosis were evaluated by Meta-analysis.Methods:As of December 2018,the electronic database in PubMed,Embase,Cochrane Library,Web of Science,Wanfang Data and China Knowledge Network uses the following keywords and MeSH terms to conduct a comprehensive search,search infrastructure:" excision repair cross-complementation group 1"("ERCC1");"Pancreatic Neoplasms" OR "Pancreatic Neoplasm" OR "Pancreas Neoplasms" OR"Pancreas Neoplasm" OR "Cancer of Pancreas" OR "Pancreas Cancers" OR"Pancreas Cancer" OR"Pancreatic Cancer" OR "Pancreatic Cancers" OR "Cancer of the Pancreas";"Cisplatin" OR "Oxaliplatin" OR "FOLFIRINOX".The quality of the literature included in the study was assessed according to the Newcastle-Ottawa Scale(NOS),followed by two independent researchers.The meaningful data from each study were extracted.The total hazard ratio(HR)and the corresponding 95%confidence interval for the relationship between ERCC1 and overall survival were calculated by Steta SE 12.0 software.(Confidence interval,C1)correlation,HR>1 indicates poor prognosis.Results:Five studies were performed in this study,and a total of 423 patients were enrolled.The random effects model was used to analyze the high level of ERCC1 in patients with pancreatic cancer,which was significantly associated with poor OS(HR=2.07,95%CI=1.31-3.28,p<0.05),Subgroup analyses indicated significant heterogeneity between studies in the RT-PCR group,and methods and cut points in studies using IHC may be more consistent than studies using RT-PCR.Conclusion:1.The high level of ERCC1 expression is negatively correlated with the efficacy and prognosis of platinum chemotherapy,which is a risk factor for platinum-based chemotherapy of pancreatic cancer and is expected to serve as a basis for individualized chemotherapy of pancreatic cancer.2.Methods and cut points in studies using IHC may be more consistent than studies using RT-PCR.