| ObjectiveTo investigate the relationship between Monocyte-to-high-density lipoprotein cholesterol ratio and target organ damage with hypertensive patients.MethodsThis investigation was carried out at Second affiliated to Kunming medical university,from march 2017 to october 2018,A total of 174patients who diagnosed as essential hypertension were particapated in the study,including 74 males and 100 females,aged 30-81 years.patients were divided into two groups according to whether there was target organ damage or not.98 patients in the target organ damage group of hypertension(TOD+)were selected as the experimental group,and 76 patients in the non-target organ damage group of hypertension(TOD-)were enrolled in the control group.At the same time,the TOD+group was divided into groups according to target organ damage indicators,one positive indicator was divided into group A,and two or more indicators were divided into group B.Record General clinical data of the selected patients,Blood was collected on the morning of the second day after fasting for blood routine,biochemical complete set,Including uric acid(UA),creatinine(Cr),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and other indicators.use echocardiogram,neck vascular ultrasound,determination of urinary albumin/creatinine(ACR),SPSS22.0 statistical software was used for statistical analysis,and relevant data among the three groups were compared,and the correlation between MHR and LVMI,CIMT and ACR levels was analyzed.,ROC(subject characteristic curve)was used to judge the diagnostic efficiency,?Results1.There were statistically significant differences in age,SBP,leukocyte,neutrophil,monocyte,LVMI,CIMT,MHR,and ACR between groups A,B,and TOD-(P<0.05).The age of group A and B was higher than that of group TOD-,and there was no difference between group A and B.SBP was significantly higher in group B than that of group TOD-,and there was no difference between group A and B.White granulocytes and neutrophils were higher in group B than in group A,and higher in group B than in group TOD-.Monocytes in groups A and B were higher than TOD-,and group B is higher than group B.In ACR,group B is higher than group A and TOD-.MHR,LVMI and CIMT were different among the three groups,and group B was higher than group A,while group A was higher than TOD-.2.Correlation analysis between general clinical data and CIMT,LVMI and ACR showed that:CIMT was positively correlated with age(r=0.335,P=0.000),monocyte(r=0.242,P=0.001),MHR(r=0.283,P=0.016),and CIMT was negatively correlated with platelet(r=-0.205,P=0.007).LVMI was positively correlated with age(r=0.342,P=0.000),SBP(r=0.229,P=0.002),neutrophils(r=0.180,P=0.017),monocytes(r=0.248,P=0.001),MHR(r=0.296,P=0.006).ACR was positively correlated with monocyte(r=0.223,P=0.004),TG(r=0.186,P=0.014),MHR(r=0.404,P=0.008),with statistically significant differences.3.correlation nalysis results showed that MHR was positively correlated with CIMT,LVMI and ACR,respectively,and the correlation coefficients were r1=0.283(P=0.016),r2=0.296(P=0.006)and r3=0.404(P=0.008).4.ROC curve showed that the area under MHR was 0.606(95%CI:0.523-0.690)When the critical value of MHR diagnosis was 0.39,the diagnostic efficiency was the highest,with a sensitivity of 63%and a specificity of 51%.Conclusion:1.The MHR in the target organ damage group of hypertension was significantly higher than that in the non-target organ damage group of hypertension.The higher the number of injuries in the target organ damage group of hypertension,the higher the MHR value.2.The MHR value is positively correlated with CIMT,LVMI and ACR,which has certain clinical application value in predicting target organ damage in early hypertension.3.When the MHR value is 0.39,it has a certain sensitivity and specificity,which has a certain guiding significance for early target organ damage of hypertension. |
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