Clinical Value Of High Frequency Ultrasound In The Evaluation Of Hemophilia Arthropathy

[Objectives]The Hemophilia Joint Health Score(HJHS)was used as a reference to investigate the clinical value of high-frequency ultrasound in evaluating hemophilia bone and joint disease,and to evaluate the efficacy of different treatments for hemophilia patients.[Methods]Ultrasound examination was performed on 122 knee joints,ankle joints and elbow joints of 61 clinically diagnosed hemophilia patients(hemophilia A58,hemophilia B3),and scored according to the MELCHIORRE hemophilia ultrasound scoring standard.At the same time,according to The Hemophilia Joint Health Score(HJHS)of 2.1,the health status of each joint was evaluated,and the correlation between the hemophilia joint ultrasound score and age,the number of bleeding,and the severity of the disease,and the HJHS score were analyzed.Relationship.Forty patients who were reviewed regularly from January 2017 to January 2018 were divided into treatment groups and on-demand treatment groups.The results were compared between the two groups.[Results]1.61 patients with hemophilia,the most common sites of joint changes were knee joint(50/61,81.96%),ankle joint(23/61,37.70%),elbow joint(18/61,29.50%).Joint diseases mainly include joint effusion/hematocele,fibrous septum,synovial thickening,synovial thickening with synovial angiogenesis,hemosiderin deposition,cartilage change,bone erosion,bone reconstruction and osteophyte formation,with detection rates of 52.3%(184/366),1.4%(5/366),59.0%(216/366),6.9%(25/366),28.1%(103/366),15.0%(55/366).),19.1%(70/366),2.7%(10/366),8.2%(30/366),respectively.and the joint ultrasound score was(4.915±1.501).2.There was no significant correlation between the ultrasound score of joints and the degree of clotting factor deficiency in patients with hemophilia(F=0.85,P=0.921),but it was closely related to age and number of bleeding.As the age and number of bleeding increased,bone and joint lesions gradually Become heavier.3.There was a significant correlation between the joint ultrasound score and HJHS2.1 score in hemophilia patients(r=0.715,P<0.01).4.Ultrasound observation of the joint status of hemophilia patients with different treatment methods showed that the degree of osteoarticular lesions in the preventive treatment group was lighter than that in the on-demand treatment group(P<0.05).[Conclusion]High-frequency ultrasound has important clinical significance for the early diagnosis of hemophilia bone and joint lesions.It can evaluate the efficacy of different treatment methods for hemophilia patients and provide imaging evidence for the effectiveness of clinical treatment programs.