QOL Study And MCID Establishment In COPD Patients

Objective:To understand the present situation of quality of life(QOL)of patients with COPD and to explore its influencing factors.To explore the relationship between quality of life(QOL)and clinical objective indexes of COPD patients,and to establish the minimum clinical important difference value of COPD,so as to provide the basis for the application of QOL in clinical treatment of COPD patients.Methods:QLICD-COPD(V2.0),SF-36,questionnaire of basic information of COPD patients and questionnaire of objective indicators of COPD patients were used to investigate the quality of life of COPD patients diagnosed and hospitalized in the Third People's Hospital of Yunnan Province from January 20,2018 to March 30,2019.The objective indicators were transcribed.SPSS22.0 statistical software package was used for data input and analysis.The main statistical methods included statistical description,t test,variance analysis,multiple linear regression,simple linear correlation and so on.Multiple linear regression was used to explore the influencing factors of quality of life in COPD patients,and correlation analysis was used to explore the relationship between quality of life score and clinical objective indicators.Minimum clinical significant difference(MCID)was determined by criteria-based and distribution-based research methods,respectively.Results:1.At the time of discharge,the quality of life of SF-36 was 58.38 ±14.65,and that of psychological synthesis was 68.54+13.74.The scores of physical pain,physiological function,mental health,social function,physiological function and energy were 73.96±13.09,73.87±33.43,70.63 ± 15.50,70.57±14.72,67.14±24.16 and 66.76±13.64,respectively.Emotional function 57.06±36.62,general health status 38.78±15.28;With the whole country.The physical function,physical pain,general health status and social function of the patients with),COPD's disease were lower than those of the national norm(P<0.05),and the physical function,physical pain,general health status and social function of the patients with the disease were lower than those of the national norm(P<0.05).The scores of emotional function were significantly higher than those of the national norm(P<0.05),but there was no significant difference in physiological function,energy and mental health between the national norm and the national norm(P>0.05).2.The patient's QLICD-COPD(V2.0)scale total quality of life score,total score of commonality module,psychological function and its will and personality side,physiological function and its lateral and specific module total score and its side at admission and discharge The difference was statistically significant(P<0.05),and the quality of life score was higher at discharge than at admission.There were no significant differences in the cognitive and emotional aspects of the social functional field and its lateral and psychological functions(P>0.05).3.The main influencing factors of patients' quality of life scores:the total scores of life quality of COPD patients and the scores of different fields in different nationalities,occupations,marital status,education level,social medical insurance were not statistically significant(P>0.05).Age,family economics,PO2,FCV,FEV1,total protein,triglyceride,calcium ion and other independent variables into the multiple linear regression equation of quality of life scores.The smaller the FCV,the larger the FEV1,the better the family economic situation,the lower the total protein content,and the higher the calcium ion content,the higher the quality of life score.4.Relationship between patient quality of life and clinical objective indicators:Correlation analysis between QLICD-COPD2.0 quality of life score and clinical biochemical test indicators in COPD patients showed that PO2,FCV,FEV1,total protein,triglyceride,sodium,chlorine,calcium and life There was a correlation between quality scores(P<0.05),but the correlation coefficient was not high.5.Minimum clinically important difference value(MCID):Based on the "10d my health condition is very good" in SF-36,the MCID is:physiological function field 17.8,psychological function field 2.27,social function field 0.56,commonality The total module area is 6.36,the specific module area is 31.12,and the total score field is 12.35.According to one SEM,the MCED is:4.37 in the physiological function field,7.26 in the psychological function field,3.73 in the social function field,4.86 in the common module total field,7.87 in the specific module field,and 4.38 in the total score field.According to the distribution method,when ES=0.5,the obtained MCID is:physiological function field 5.73,psychological function field 10.09,social function field 5.19,common module total field 6.07,specific module field 9.84,scale total field 5.86.Conclusion:The quality of life of COPD patients is not high,and the scores of quality of life at discharge are significantly improved compared with those at admission.The factors affecting quality of life are age,family economic situation,P02,FCV,FEV1,total protein,triglyceride and calcium.P02,FCV,FEV1,total protein,triglyceride,sodium,chloride,and calcium were correlated with quality of life scores.The MCID was established by the criterion method and the distribution method.Finally,when the ES=0.5 in the distribution method,the obtained MCID is the final result.