The Clinical Study Of Yiliu Xiaohe Decoction Combined With R-CHOP Regimen In Diffuse Large B-cell Lymphoma

Objective:To observe the effect of Yiliu Xiaohe Decoction combined with R-CHOP regimen on lesion size,tumor burden,TCM syndrome,physical strength and chemotherapy toxicity of patients with diffuse large B-cell lymphoma,and to evaluate the clinical efficacy of YiliuXiaohe Decoction combined with R-CHOP chemotherapy regimen,then to providemore scientific and sufficient clinical evidence for the prescription widely used.Methods:In this study,62 patients with DLBCL were enrolled in the Department of Hematology of Gansu Provincial Cancer Hospital.They were eligible for DLBCL western medicine diagnostic criteria and TCM syndrome differentiation,and randomly divided the 62cases into control group?n=31?and treatment group?n=31?.All patients voluntarily signed informed consent.Control group was treated with standard R-CHOP regimen,and the treatment group was treated with Yiliu Xiaohe Decoction on the basis of the control group.The curative effect was evaluated after 4 cycles of treatment?21 days for a cycle of treatment?.The changes of lesion size,tumor burden,TCM syndrome,physical strength and chemotherapy toxicity were observed before and after treatment.All data were analyzed by SPSS 23.0 statistical software.P<0.05 was considered statistically significant.Results:During the observation period,3 patients fell off,and 59 patients were actually included in the statistical analysis?29 in the control group and 30 in the treatment group?.The results are as follows:?1?The effective rate of lesion change after treatment in the two groups:in the control group,2 cases of Complete remission,8 cases of Unconfirmed complete remission,12 cases of Partial response,and the total effective rate was 75.86%;In the treatment group,4 cases of complete remission,11 cases of Unconfirmed complete remission,11 cases of Partial response,and the total effective rate was 86.67%.The short-term effect of the control group and the treatment group was similar?P>0.05?.?2?Comparison of tumor burden after treatment:the LDH and?₂-MG indexes in the control group and the treatment group were lower than those before treatment?P<0.05?,and the decrease in the treatment group was significantly better than that in the control group?P<0.05?.?3?Comparison of TCM syndromes after treatment in the two groups:in the control group,2 cases were marked excellent,13 cases were effective,and the total effective rate was 51.72%;In the treatment group,1 cases were clinical cured,6 marked as excellent cases,16 were effective cases,and the total effective rate was 76.67%.The efficacy of TCM syndromes in the treatment group was significantly better than that in the control group?P<0.05?.?4?Comparison of physical strength after treatment:the physical strength scores of the control group and the treatment group were improved compared with those before treatment?P<0.05?,and the physical strength score of the treatment group was significantly better than that of the control group?P<0.05?.?5?Comparison of chemotherapy toxicity after treatment in the two groups:the incidence and degree of hematological toxicity,digestive tract reaction and neurotoxicity in the treatment group were lower than those in the control group?P<0.05?.There was no significant difference in liver and kidney function damage and cardiotoxicity?P>0.05?.?6?During treatment,one patient in the treatment group developed mild allergic reaction when the first infusion of rituximab,and the symptoms disappeared after symptomatic treatment such as anti-allergic treatment,and the infusion was resumed from fast to slow.There were no serious adverse reactions;There were no significant differences in electrocardiogram,urine routine,fecal routine,liver function and renal function tests between the two groups before and after treatment.Conclusion:?1?Yiliu Xiaohe Decoction combined with R-CHOP regimen in the treatment of DLBCL can better alleviate clinical symptoms,improve TCM syndrome,reduce tumor burden,restore physical strength and improve clinical efficacy compared with chemotherapy alone;?2?Yiliu Xiaohe Decoction combined with R-CHOP regimen in the treatment of DLBCL can significantly reduce the incidence of blood toxicity,digestive tract reaction and peripheral neurotoxicity caused by chemotherapy,and reduce the degree of chemotherapy toxicity compared with chemotherapy alone.It is safe and reliable.