Expression Of Nrf2 And HO-1 In Gastric Cancer And Their Clinical Significance

Objective:The present study aimed specifically investigate the expression and correlation of Nuclear factor erythroid-2-related factor-2(Nrf2)and heme oxygenase?1(HO?1)in gastric cancer and their association with clinicopathological features.Methods:Gastric cancer tissues from a total of 60 patients during surgical resection were examined for Nrf2 and HO-1 expression profiles using IHC staining on paraffin-embedded slides.Between-group-comparisons were performed by chi-square analysis.The spearman correlation analysis was used to analyze the relationship between Nrf2 and HO-1 expression.Results:Nrf2 immunoreactivity was predominantly identified in the nucleus of gastric cancer cells.Nrf2 positivity was closely associated with tumor size,tumor depth,lymph node metastases,differentiated degree and stage(P < 0.05 for all).HO-1 immunoreactivity was predominantly identified in the nucleus of gastric cancer cells.HO-1 positivity was closely associated with tumor size,tumor depth,lymph node metastases,differentiated degree and stage(P < 0.05 for all).Spearman correlation analysis showed that there was a positive correlation between Nrf2 and HO-1 expression(Spearman correlation coefficient 0.356,P<0.05).Conclusion:Expression of Nrf2 and HO-1 was positively associated with aggressive tumor behavior in gastric cancer.This result suggests that expression of Nrf2 and HO-1 in gastric cancer is a potential indicator of worse prognosis.