The P53 Protein Expression And Its Association With The Recent Curative Effect After Neoadjuvant Chemoradiotherapy In Rectal Cancer

Objective:To explore the relationship between the expression level of p53 protein and the recent curative effect after neoadjuvant chemoradiotherapy in rectal cancer.Methods:A retrospective analysis was performed on clinical and pathological data of41 patients with rectal cancer,who underwent neoadjuvant chemoradiotherapy in Liaoning cancer hospital from 2014 to 2017,immunohistochemistry was used to detect the expression level of p53 protein in 41 rectal cancer tissues before neoadjuvant chemoradiotherapy,Mandard tumor regression grade was used as the standard of the recent curative effect after neoadjuvant chemoradiotherapy,the predictive value of the expression level of p53 protein and clinical features(including gender,age,clinical stages before therapy,diameter of tumor before therapy)were analysed.Results:The p53 protein differently expressed in 41 rectal cancer tissues.The high expression of p53 protein group had 15 cases(36.6 %),the low expression of p53 protein group had 26 cases(63.4 %).The expression level of p53 protein was correlated with the recent curative effect after neoadjuvant chemoradiotherapy(P=0.004).Higher expression level of p53 protein in rectal cancer indicated poor recent curative effect to neoadjuvant chemoradiotherapy than the lower.Multivariate logistic regression analysis showed that the expression level of p53 protein(P=0.013)、clinical stages(Ⅱ/Ⅲ)before therapy(P=0.017)and diameter of tumor before therapy(P=0.013)were independent predictive factors for the recent curative effect after neoadjuvant chemoradiotherapy.Conclusions:1.Correlation between the expression level of p53 protein and the recent curative effect after neoadjuvant chemoradiotherapy may exist,which may be helpful in predicting the recent curative effect after neoadjuvant chemoradiotherapy in rectal cancer,patients with lower expression level of p53 protein in tumor tissues may benefit more.2.The expression level of p53 protein 、 clinical stages(Ⅱ/Ⅲ)before therapy and diameter of tumor before therapy might be three predictive markers of the recent curative effect after neoadjuvant chemoradiotherapy for patients with rectalcancer.3.Age and gender had little affect on the recent curative effect after neoadjuvant chemoradiotherapy for patients with rectal cancer.