The Correlation Between Serum NLRP3 Level And Nonalcoholic Fatty Liver Disease In Type 2 Diabetes Mellitus

Objective:To investigate the correlation between serum NLRP3 level and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus.Methods:A total of 118 patients with type 2 diabetes mellitus hospitalizad at the Hospital from January 2017 to July 2018 were collected.The type 2 diabetes mellitus patients were divided into 67 patients with NAFLD as the experimental group and 51patients with non-NAFLD as the control group according to abdominal ultrasonography.The serum NLRP3 level were measured by ELISA.T test or?~2 test were used to analyze the differences the measurement index between the two groups.The correlation compare used analysis,and Logistic regression was used to explore the risk factors of NAFLD.Results:1.The measurement index,such as BMI,the serum levels of FPG,fasting c-peptide,HOMA-IR,TG,GGT,AST,ALT,UA,WBC,NLRP3 were obviously in patients with NAFLD,the difference was statistically significant(P<0.05).2.NLRP3was positively correlated with BMI,HOMA-IR,FPG,fasting c-peptide,fasting insulin,TC,TG,GGT,AST,UA and WBC(P<0.05).3.Logistic regression analysis indicated that TG,AST and NLRP3 were risk factors in T2DM with NAFLD.Conclusion:Serum levels of NLRP3 were significantly increased in patients with type 2 diabetes mellitus accompanied by nonalcoholic fatty liver disease.High NLRP3 level may be closely related to the occurrence of NAFLD in type 2 diabetes.