| Objective: glioma,the most common primary intracranial tumor,originated in the glial cells,the rate was highest for Glioblastoma(GBM Glioblastoma,WHO ? level),accounted for 46.1%,followed by diffuse astrocytoma,treatment with surgical removal of the tumor,and combined with radiotherapy,chemotherapy and other comprehensive treatment method,but the prognosis of patients with universal is poorer,searching for new molecular targets for prediction and prolong survival in patients with stage is of great significance.By means of immunohistochemistry,the expression of opioid growth factor receptor in human glioma was studied,and the relationship between the expression level and the grade of glioma was demonstrated,as well as the correlation between the expression level and the prognosis of patients.Methods: 69 cases of glioma diagnosed by paraffin pathology of tumor tissue after operation in shengjing hospital affiliated to China medical university on January 1,2013 and June 31,2018 were selected.Immunohistochemistry SP method was used to detect the expression of OGFR in 69 cases of human brain glioma tissues,and correlation analysis was conducted with the prognosis.Results: OGFR was proved to be expressed in most of the collected specimens,and the expression level increased with the malignant degree of glioma,and the difference was statistically significant.However,the expression of OGFR was not correlated with other pathological features and was an independent influencing factor.Kaplan-meier survival curve analysis showed that the prognosis of patients with positive OGFR expression was significantly better than that of patients with negative OGFR expression.Conclusion: opioid growth factor receptors exist in human gliomas,which are upregulated with tumor malignancy and affect the prognosis of patients. |
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