Correlation Between Preoperative Serum CEA?CA19-9 Level?Clinicopathological Factors And Prognostic In Patients With Resectable Hilar Cholangiocarcinoma

Objective: To investigate the correlation between preoperative serum CEA ? CA19-9levels and clinicopathological factors in patients with resectable hilar cholangiocarcinoma(HC),and to analyze the correlation between the above factors and the postoperative survival rate of these patients further.Methods: The Clinical and pathological data of 109 patients with HC who underwent radical resection from January 2012 to January 2018 in Shengjing Hospital affiliated to China Medical University were retrospectively analyzed.The correlation between preoperative serum CEA/CA19-9 level and clinicopathological features and the correlation between the above factors and the postoperative survival rate of these patients were analyzed.Results: 1)There is no significant correlation between clinicopathological features of HC and preoperative CEA level(P>0.05).2)The more severe the preoperative jaundice get,the higher the serum CA19-9 level is(P<0.05).3)The preoperative serum CA19-9 level is relatively high in patients with vascular invasion(P<0.05).4)The later the TNM stage is,the higher the preoperative serum CA19-9 level is,and the difference is statistically significant(P<0.05).5)Portal vein invasion,lymph node metastasis,TNM staging and preoperative serum CA19-9 level are risk factors for 1-year survival rate of HC patients who underwent radical resection(P < 0.05).Among them,lymph node metastasis,portal vein invasion and preoperative serum CA19-9 level are independent risk factors for1-year survival rate of these patients.Conclusion: Preoperative serum CA19-9 level in patient with resectable HC are correlated with clinical stages and vascular invasion.Early HC patients have better prognosis after radical resection,and increasing the early diagnosis rate of HC is helpful to improve the survival and prognosis of HC patients.Preoperative serum CA19-9 level,portal vein invasion and lymph node metastasis can be used to predict the survival rate of HC patients after radical resection.Periodically postoperative review should also be an important link in the diagnosis and treatment of patients with resectable HC.