| Objective: Using low frequency amplitude(ALFF)to explore the differences of spontaneous brain activity by Resting-state functional magnetic resonance imaging and to investigate the potential correlation among the ALFF values,pain intensity,course,and emotion disorders in patients with postherpetic neuralgia(PHN)in chest and back with emotion disorders.Methods: From June 2017 to December 2018,23 patients diagnosed as PHN with emotional disorder in pain department were collected as experimental group and 23 healthy adults with matched age,sex and education level as control group.Siemens 3.0T full-body magnetic resonance imaging equipment was used to measure the level of blood oxygen saturation(Blood Oxygen Level Dependent,BOLD)data acquisition.The brain regions with difference between the two groups were obtained by DPABI software pretreatment and statistical analysis(GRF correction,P<0.01).The results showed that there was significant difference between the two groups(P<0.05),and Pesrson correlation analysis was made between ALFF value of brain area and course of disease,VAS score and HAMD score between the two groups(P<0.05).Results: Compared with the control group,PHN group showed signifcantly higher ALFF value in bilateral thalamus,bilateral parahippocampal gyrus,bilateral putamen,left inferior temporal gyrus,and left fusiform gyrus(P<0.01,GRF correction).Conclusion: There are abnormal activated brain regions in patients with PHN with emotional disorders,which are related to pain perception,pain regulation and emotional processing.These areas provide preliminary imaging evidence for exploring the underlying emotional disorders in PHN patients. |
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