| Objectives To explore the association of serum levels of apelin or carnosine with white matter hyperintensities and identify the relationship between apelin or carnosine and the classification of white matter hyperintensities.Methods Randomly recruit 300 cases of hospitalized patients from July 2015 to August 2016 in our department of neurology,with high risk factors of cerebrovascular disease,149 females and 151 males were included with the average age of 67.4±11.05,and 72 cases were without white matter hyperintensities,228 cases with white matter hyperintensities.94 cases were complicated with lacunar infarction.Use the scale of Fazekas in periventricular hyperintensity,deep white matter hyperintensity and white matter hyperintensities to divide the patients into four groups,which include Grade 0,Grade 1,Grade 2 and Grade 3.The basic clinical data,previous history associated with common vascular risk factors,laboratory tests results were collected and analyzed as baseline data.The serum concentrations of apelin and carnosine were detected with enzyme linked immunosorbent assay(ELISA)and compared among four groups.Correlation analysis was performed between apelin or baseline data and classification of white matter hyperintensities.Multiple logistic regression was used to analyze whether apelin or carnosine are independently associated with white matter hyperintensities.Results 1.single-factor and correlation analysis of baseline data: there are statistical differences among four groups on age,hypertension,HCY,FIB,hs CRP and TG,P<0.05;age, hypertension,HCY,FIB and hs CRP are associated with classification of white matter hyperintensities and correlation coefficients are as follows respectively: 0.479(P=0.000),0.225(P=0.000),0.203(P=0.003),0.136(P=0.028).2.single-factor and correlation analysis of concentrations of serum apelin and carnosine: there is statistical differences among four groups on serum apelin levels.In the multiple comparison of apelin,there are statistical differences between any two groups except Grade2 VS Grade3;there is no statistical difference among four groups on carnosine.Serum apelin level is associated with classification of white matter hyperintensities,(r=0.671,P=0.000),and the correlation coefficients of Grade 1,Grade 2 and Grade 3 are as follows: 0.229(P=0.047),0.729(P=0.000),0.717(P=0.000);Apelin is weakly associated with perventricular hyperintensity and deep white matter hyperintensity and the correlation coefficients are as follows,respectively: 0.322(P=0.000),0.27(P=0.001).3.Mutiple logistic regression: apelin(Grade 2: OR=1.003,95%CI: 1.000-1.003,P=0.035;Grade 3: OR=1.003,95%CI: 1.000-1.003,P=0.026),age(Grade 1: OR=1.394,95%CI: 1.054-1.843,P=0.02;Grade 3: OR=1.343,95%CI:1.028-1.754,P=0.03)and hypertension(Grade3: OR=182.462,95%CI: 1.068-31174.48,P=0.047)are independently associated with white matter hyperintensities.Conclusions 1.Compared with patients without or with mild white matter hyperintensities,serum concentration of apelin in patients with moderate-severe white matter hyperintensities is much higher.There is no significant difference among four groups on the serum concentration of carnosine.2.Serum apelin level is significantly associated with white matter hyperintensities,especially with moderate-severe white matter hyperintensites.3.Age and hypertension are independent risk factors of classification of white matter hyperintensities.After adjusted for age and hypertension,apelin has a predictive value on moderate-severe white matter hyperintensities to some extent.Patients with a higher serum level of apelin maybe have a higher risk in developing into moderate-severe white matter hyperintensities... |
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