PET/CT In The Preoperative Assessment For Endomentrial Cancer And Ovarian Cancer

Objective:To evaluate the clinical value of 18F-FDG PET/CT in preoperative assessment for endometrial cancer and ovarian cancer.Methods:A retrospective study was performed in 51 patients(average age(59±12)years)with endometrial cancer and 53 patients(average age(55±16)years)with ovarian cancer skeptically from November 2012 to December 2015,33 patients with endometrial cancer were performed curettage surgery at least 1 week before PET/CT imaging.SUVmax for tumor were explored in benign and malignant patients with endometrial cancer and ovarian cancer,.respectively.The invasive extent,histologic grade and subtype of primary tumor were explored by SUVmax for tumor in patients with endometrial cancer,lymph node metastases and other metastases also were analyzed in patients with endometrial cancer.Implantation metastasis in enterocoelia were analyzed in patients with ovarain cancer.Two-sample t test was used to analyze the data,and diagnostic efficacy of PET/CT for metastasis was calculated.Results:There were 43 patients with endometrial cancer and 8 patients with benign uterine tumor.SUVmax was significantly related to histopathology classification(benign: 3.4 ± 1.2,malignant: 12.8 ± 6.5)and myometrial invasion deep(? 1/2: 17.7±5.4,<1/2: 10.9±5.9;t=-8.7and3.2,both P<0.05),but insignificantly related to cervical stroma invasion,histologic grade and histologic subtype(t=1.8?-1.9?1.5,all P>0.05).There were 32 patients with ovarian cancer and 15 patients with benign ovarial tumor and 6 patients with borderline ovarial tumor,SUVmax was significantly in benign an malignant ovarial tumor(malignant:13.3 ±5.4,benign: 4.7±3.6)and in borderline and malignant ovarial tumor(malignant:13.3±5.4,benign:3.6 ± 2.1,t=6.2and4.3,both P<0.05).In patients with endometrial cancer,the sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of PET/CT for the detection of lymph node metastases by lesions were 85.7%(18/21),98.2%(271/276),97.3%(289/297),78.3%(18/23),98.9%(271/274),respectively,which were6/6,97.3%(36/37),97.7%(42/43),6/7,100%(36/36),respectively for the detection of other metastasis by cases.The sensitivity and PPV of PET/CT for the detection of other metastases by lesions were 11/12 and 11/12,respectively.In patients with ovarian cancer,the sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of PET/CT for the detection of implantation metastasis in enterocoelia were 100%(10/10),78.6%(11/14),87.5%(21/24),76.9%(10/13),100%(11/11),respectively.Conclusion : SUVmax could serve as PET/CT represents a clinically valuable tool for preoperatively evaluating the presence of deep myometrial invasion,lymph node metastases and other metastases in endometrial cancer,and implantation metastasis in enterocoelia in ovarian cancer,and can be applied in preoperative assessment of endometrial cancer and ovarian cancer.