Study On Body Mass Index And Metabolic Index In Elderly Type 2 Diabetic Patients

Objective In this study,elderly patients with type 2 diabetes mellitus (T2DM)who were hospitalized were selected as the subjects.The relationship between obesity and metabolic indices was explored by studying metabolic indices(some blood biochemical indices,blood sugar metabolic indices,homocysteine,etc.)of two groups of patients with different body mass index(BMI).Methods A total of 491 patients with T2DM admitted to the Department of Endocrinology,The First Hospital Of Lanzhou University from June 2014 to March 2018 were enrolled.All subjects enrolled in the study were limited to over 60years of age.Referring to the criteria of obesity classification in China,491 patients with T2DM were divided into two groups with 24 kg/m~2 BMI as the dividing point:N1 group(18.5?BMI<24 kg/m~2)was normal weight group(213 cases)and N2 group(BMI?24 kg/m~2)was overweight and obesity group(278 cases),of which 229 cases were overweight and 49 cases were obese in N2 group.The data were processed by SPASS.21 statistical software.The basic conditions,insulin use,alcohol and tobacco hobbies,laboratory test indicators,comorbidities and common complications were compared to explore the relationship between BMI and metabolic indicators in elderly patients with T2DM.Result(1)There were no differences in gender,age,nationality and course of diabetes mellitus(DM)between N1 and N2 groups(P>0.05).(2)Compared with the N1 group,the incidence of hypertension was higher in the N2 group(52.6%,70.1%in the N1 group and N2 group,respectively),and the incidence of osteoporosis was lower(39.9%,27.0%,respectively),and the differences were statistically significant(P<0.05);there were no difference in complications of cerebral infarction(8.9%,9.0%)and coronary heart disease(6.6%and 6.1%,respectively)between the two groups(P>0.05).(3)There were significant differences in the complications of diabetes-related nephropathy(34.3%,45.0%)and retinopathy(51.6%,61.2%)between N1 group and N2 group,and the differences were statistically significant(P<0.05).(4)Compared with N1 group,GGT,UA,TG,LDL-C,fasting C-peptide and IRI were higher in N2 group,the differences were statistically significant(P<0.05);The N2 group had lower levels of HDL-C,and the difference was statistically significant(P<0.05).(5)Pearson correlation analysis:BMI was positively correlated with systolic blood pressure,ALT,GGT,UA,LDL-C,postprandial 2h C-peptide,fasting C-peptide,IRI(correlation coefficients were 0.09,0.12,0.15,0.18,0.09,0.09,0.09,0.21respectively),but negatively correlated with HDL-C(correlation coefficient was-0.10),the differences were statistically significant(P<0.05).(6)Logistic regression analysis:The results showed that GGT and UA were risk factors for obesity in elderly T2DM.Conclusion The metabolic effects of obesity on elderly patients with T2DM are multifaceted,which may affect liver function,uric acid,blood lipids and glucose metabolism to varying degrees.Obesity has a significant driving effect on improving the incidence of chronic complications and common complications in elderly patients with T2DM.This part of the population should actively and reasonably control body weight,actively intervene in the presence of dyslipidemia,hyperuricemia and abnormal glucose metabolism to improve the quality of life and prolong life of elderly T2DM patients.