| Background and purpose As one of the most common malignancies in the world,the prognosis of gastric cancer is worse than that of other malignancies,which has a serious impact on human health.According to the statistical data of the international agency for research on cancer,there were about 951,000 new cases of gastric cancer in the world in 2012.China is a large country where gastric cancer occurs,and the new cases of gastric cancer were mainly concentrated in China.The number of cases and deaths of gastric cancer in China accounted for 42.6%and 45.0%of the global incidence and deaths of gastric cancer,respectively.Meanwhile,compared with Japan and South Korea,the diagnose rate of early gastric cancer in China is far lower than that in Japan and South Korea.Since most patients with early gastric cancer have no obvious clinical symptoms and cannot be paid enough attention to,most of the patients with gastric cancer in China have developed to advanced gastric cancer at the time of initial diagnosis,which has seriously affected the prognosis of patients and the mortality of patients with gastric cancer.At present,although the survival rate of gastric cancer patients can be greatly improved through surgery,chemotherapy,radiotherapy and other methods,the curative effect is still not optimistic and has not reached the expected effect,so it is urgent to find new methods and new entry points to better and more effective treatment of gastric cancer.Since the successful implementation of gene therapy for adenosine deaminase deficiency in 1990,gene therapy has been applied in the field of cancer treatment and become a new breakthrough point of cancer treatment.The introduction of tumor suppressor genes is an important strategy for tumor gene therapy,and screening and discovery of tumor suppressor genes is a prerequisite for tumor therapy.In this study,the expression characteristics of filaggrin A(FLNa)in gastric tumor tissues and normal gastric mucosal tissues were observed,and the correlation between its expression and clinical parameters,survival period and prognosis of patients was analyzed in combination with clinical parameters of patients.Methods Immunohistochemistry was used to detect FLNa expression in 51 cases of gastric tumor tissues and normal gastric mucosa tissues selected from affiliated hospital of hebei university,and the correlation between FLNa expression in gastric tumor tissues and the survival and prognosis of patients with clinical parameters was analyzed.Results 47.1%of the gastric cancer tissues expressed FLNa while 90.2%of the normal gastric tissues did the same.This difference was statistically significant(?~2=34.622,P=0.000).FLNa expression correlated with lymph node metastasis and depth of gastric wall invasion(P<0.05),regardless of gender,age,locus,Borrmann's type and histological type(P>0.05).Multivariate Cox regression model analysis showed that lymph node metastasis,depth of tumor invasion and FLNa expression level was independent factors that affect prognosis after surgery.The death risk of cases expressed FLNa was 2.013 times as the rate o f cases that did not expressed FLNa and the fiducial interval(95%)lies between 0.001-0.159.The average survival and the median survival time of the cases that expressed FLNa was 60.9±2.1 and63.0±0.8 months,respectively.However,the corresponding survival time of cases expressed no FLNa was only 23.8±2.2months and 23.0±1.4 months,respectively.Log-rank test showed that the deference between them is statistically significant(P=0.000).Conclusions Expression level of FLNa in gastric cancer tissue is statistically lower than that in normal gastric tissue and this phenomenon obviously correlated to the gastric tumorigenesis and survival time on patients with gastric cancer. |
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