| Purpose: Lung cancer is a globally high-risk cancer.According to the latest global cancer morbidity and mortality statistics,lung cancer has the highest morbidity and mortality rates among the two sexes.Most of the primary lung cancers have no obvious clinical symptoms in the early stage,and they are already locally advanced or distant metastasis at the time of discovery.After the patient lost the opportunity for early surgical radical resection,he was mainly treated with comprehensive treatment.With the advancement of science and technology,the discovery and technology in the medical field are changing with each passing day,various anti-tumor drugs are not being cross-cutted,and various treatment programs are constantly improving,which significantly prolongs the survival of patients with advanced lung cancer and improves the quality of life of patients..Lung cancer is a heterogeneous disease that is extremely important and challenging to treat individualized treatment options for different patients.Therefore,it is necessary to develop a simple and reliable biological indicator to predict the prognosis of patients and to help achieve individualized treatment options.Thioredoxin reductase is one of the key regulatory enzymes in the process of abnormal proliferation of malignant tumors.It is overexpressed in many malignant tumors and can be used to assist in the diagnosis of malignant tumors.However,the specific effects of thioredoxin reductase on the efficacy and prognosis of patients with advanced lung cancer remain unclear.This study was to investigate the effect of thioredoxin reductase expression on the efficacy and prognosis of patients with advanced non-small cell lung cancer.Methods : Peripheral blood of patients with advanced non-small cell lung cancer hospitalized in our hospital from January 2017 to December 2018 was collected,and thioredoxin reductase was detected using a thioredoxin reductase assay kit.The clinical and pathological features,recent review and long-term survival data of all patients were collected and analyzed by SPSS software.The expression of thioredoxin reductase in adenocarcinoma patients and squamous cell carcinoma patients was analyzed.Further,8U/ml is a refractory point of thioredoxin reductase,which is higher than the high expression level group,and lower than the low expression level group,the thioredoxin reductase high expression group and low expression are analyzed.Differences in disease control rates between the groups to investigate the relationship between thioredoxin reductase expression and prognosis in patients with advanced non-small cell lung cancer;single factor COX and multivariate analysis to analyze the correlation between carcinoembryonic antigen and overall survival of patients;Type of impact on overall patient survival.Results : A total of 311 patients were enrolled in this research from January 2017 to December 2018.After excluding patients who were clinically satged as early or postoperative,and those with pathological types of small-cell-lung-cancer,the remaining was 235 cases,including 140 male and 95 female.According to the classification of pathological types,it was divided into 209 adenocarcinoma and 26 squamous carcinoma.1)The result showed that there were no significant differences that were found from clinical variables.2)With the cut-off value of 8U/ml,the lower serum Trx R activity patients had better desease-control rate(DCR,82.7% vs 65.6%,p=0.003),compared with higher patients.3)The basic clinical characteristics have a certain impact on the overall survival period of patients.Female patients are superior to male patients,adenocarcinoma patients are superior to squamous cancer patients,high and middle differentiation are superior to low-differentiation patients,and non-lymph node metastasis patients are superior to patients with lymph node metastasis.Patients with a history of surgery are superior to patients with no history of surgery.After further stratification,the same conclusion was reached in patients with TR ? 8U/ml and TR > 8U/ml.4)Univariate analysis showed that the serum level of carcino-embryonic antigen was related to OS(HR=1.000,95%CI 1.0000-1.0003,P=0.040).Multivariates analysis showed that pathological pattern were significantly corelated with OS.Comparing with the squamous caicinoma,the adenocarcinoma of lung had longer overall survival(HR=0.148,95%CI 0.031-0.707,P=0.017).Conclusions : The basic clinical characteristics have some influence on the overall survival period of lung cancer patients.Patients with lower expression levels of Trx R had better immediate outcomes.The pathological pattern of patients with non-small-cell-lung-cancer could be a prognosis indicator of prognosis in patients. |
PDF Full Text Request