| Objective:It is a piece of research on the validity and safety of using fasudil aerosol inhalation,a kind of Rho kinase inhibitor,for patients with Pulmonary Artery Hypertension?PAE?.Methods:The research was carried out with dual center,random,comparison and open methods.60 patients with PAE were selected from May 2014 to Dec.2014 in Department of integrated traditional Chinese and Western Medicine of Tianjin First Central Hospital and Tianjin occupational disease prevention and treatment hospital.The Pulmonary Artery Pressures?PAPs?of the patients conformed to the criteria.It means the Mean Pulmonary Arterial Pressure?MPAP??25mmHg in quiescent condition or the MPAP>30mmHg in state of motion.The statistical results were calculated with random number table under SPSS software.The 60 patients were randomly divided into comparison group and treatment group with 30 patients in each group.The comparison group was treated ordinarily.The treatment group was given the aerosol inhalation of fasudil injection as well as the ordinary treatment.The course of the two groups was of 7 days.The main clinical symptom grading and the ultrasonic cardiogram were evaluated before and after the treatment.And flup was taken after 30 days.The project had been ethical and the Ethics committee of Tianjin First Central Hospital and Tianjin occupational disease prevention and treatment hospital agreed to carry out it.The treatment group was treated with the 7-days'aerosol inhalation of fasudil injection with 60ml once a day besides the treatments to the comparison group.General indications and clinical symptoms such as body temperature,heart rate,blood pressure,breathing rate,weight and the clinical symptoms of chest pain,spitting blood,dry cough,faint,hoarseness,breathing hard and etc.,were observed and recorded.Both the ultrasonic cardiogram and the vital of the 7th day signs were recorded.The experimental data was statistical analyzed with the SPSS1 7.0.The chi-square test(?2)was adopted in comparing the enumeration data of the two groups,the measurement data was signed by mean±standard deviation?x±s?,t-test is employed to compared the sample mean of the two groups and the analysis of variance is used in diversity of the mean which is statistical significance with the difference of p<0.05.Results:1.The ordinary clinical characteristics of the research objects:the two kinds of rate of the PAH and the symptom curative effect index?p<0.05 above?of the treatment group are higher than the comparison group,and the difference is significant,while it is not significant on the comparison of the two groups either in age or gender?p>0.05?.2.Both the measured PAH and the symptom curative effect index of the treatment group?the group with fasudil aerosol inhalation?and the comparison group are reduced obviously?p<0.05?.The reduction degree of the PAH and the symptom curative effect index of the treatment group is higher than those of the comparison group?p<0.05?.Conclusions:1.Fasudil hydrochloride aerosol inhalation can drop patients with PAH.2.Clinical signs and symptoms such as chest pain,spitting blood,dry cough,faint,hoarseness and breathing hard are relieved after the fasudil aerosol inhalation is adopted.3.Fasudil hydrochloride aerosol inhalation is safe for curing patients with PAH. |
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