The Changes Of B Cell-activating Factor And A Proliferation-Inducing Ligand In Serum Of Children With Henoch-schonlein Purpura Nephritis

Objective:To investigate the changes of B cell-activating factor(BAFF)and a proliferation-inducing ligand(APRIL)in serum of children with Henoch-Schonlein purpura nephritis(HSPN),and to explore their role in the pathogenesis of children HSPN.Methods:A total of twenty-eight children with HSPN who were before treatment were selected in Department of Pediatrics Nephnology,Shengjing Hospital of China Medical University from November 2017 to August 2018.Sixteen children with henoch-Schonlein purpura(HSP group)and twenty health children(control group)were selected as control.Followed the HSPN guideline to cure the patients for six-eight weeks,we got twenty children as after treatment group.The clinical data were collected.Serum levels of BAFF and APRIL were measured by adopting enzyme-linked immunosorbent assay(ELISA).Results: 1.Changes of serum BAFF level The serum levels of BAFF in HSPN children were significantly lower than those in the HSP group and healthy control group.[ HSPN group(0.728±0.340)μg/L,HSP group(1.276±0.459)μg/L,healthy control group(1.285±0.299)μg/L,F = 23.715,P = 0.000].Moreover,the serum levels of BAFF in before treatment group were significantly lower than in after treatment group.[before treatment group(0.652±0.354)μg/L,after treatment group(0.860±0.262)μg/L,P<0.05).However,there was no significant difference in the serum levels of BAFF between HSP group and control group(P>0.05).2.Changes of serum APRIL level The serum levels of APRIL in HSPN and HSP children were both significantly higher than those in healthy control group,but there were no marked differences between the two groups.[HSPN group(2.197±0.911)μg/L,HSP group(2.609±1.264)μg/L,healthy control group(1.677±0.118)μg/L,F = 5.099,P = 0.008 ].There was no significant difference in the serum levels of APRIL between before treatment group and after treatment group.[ before treatment group(2.285±1.015)μg/L,after treatment group(2.042±0.695)μg/L].3.Pearson correlation analysis results showed that the serum levels of BAFF were negatively correlated with 24 h urinary protein,urinary microalbumin,and urine red blood cell count(all P<0.05).The serum levels of APRIL were positively correlated with serum Ig A(P<0.05).Conclusions:The level of serum BAFF decreased and APRIL increased in children with HSPN,which was related to the degree of renal involvement.It suggests that BAFF and APRIL may be related to the pathogenesis of HSPN in children.