Study On The Relationship Between High-sensitivity C-reactive Protein And The Severity Of Coronary Artery Lesions And Short-term Prognosis In Patients With Acute Myocardial Infarction After PCI

Objective: To investigate the relationship between high-sensitivity C-reactive protein(hs-CRP)and severity of coronary artery lesions and short-term prognosis after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods: A total of 179 patients with acute myocardial infarction who underwent successful PCI from October 10,2017 to October 29,2018 in our hospital were selected.The level of hs-CRP was measured within 48 hours after operation.All patients were recorded for clinical data,blood samples,cardiac function,and whether major adverse cardiovascular events(MACE)occurred within 3 months after operation.According to the hs-CRP level,it can be divided into high hs-CRP group(>3mg/L)and low hs-CRP group(≤ 3mg/L),including 134 cases in high hs-CRP group and 45 cases in low hs-CRP group.According to the results of coronary angiography,the degree of coronary artery lesions was quantified by SYNTAX score.The correlation analysis between the two groups was carried out by statistical methods such as chi-square test,t-test and non-parametric rank sum test.According to the follow-up patients with or without MACE,they can be divided into MACE group and no MACE group,including 32 cases in MACE group and 147 cases in no MACE group.Univariate logistic regression and multivariate logistic regression analysis were used to study the correlation between various factors and MACE.Results: 1.The SYNTAX scores in the high-hs-CRP group and the low-hs-CRP group were statistically significant(P<0.05).There was significant difference in troponin I between the two groups(P<0.01).2.Univariate analysis showed that hs-CRP,SYNTAX score and number of stents were associated with short-term prognosis in patients with AMI.Multiple regression results showed that hs-CRP(OR=1.010,95%CI(0.998~1.022),P=0.116)was not associated with the recent occurrence of MACE in patients with AMI.Conclusion: 1.The level of hs-CRP after PCI was significantly correlated with the severity of coronary artery disease and the degree of myocardial injury in patients with AMI.2.A single measurement of hs-CRP levels after PCI does not predict the short-term prognosis of patients with AMI.