Expression And Significance Of Peroxiredoxins And NF-κB In Vulvar Lichen Sclerosis And Vulvar Squamous Cell Carcinoma

Objective : To investigate the expression of Prxs and NF-κB proteins in VLS and VSCC.Methods: We used immunohistochemical method to detect the expression of Prxs and NF-κB proteins in VLS and VSCC as well as normal vulva skin,analysed the relationship of Prxs and NF-κB with clinical and pathological data.Results: The expression of Prxs in VLS and VSCC was significantly higher than that in normal vulva skin(p<0.05).Higher expression Prxs was observed in stage III-IV of VSCC(p<0.05),with lymph node metastasis(p<0.05)and the moderate differentiation of VSCC(p<0.05).The expression of NF-κB in VLS was significantly lower than that in normal vulva skin,on the contrary NF-κB was higher expression in VSCC(p<0.05).NF-κB expression in stage III-IV was higher than that of stage I-II(p<0.05),with lymph node metastasis was higher than that without lymph node metastasis(p<0.05),with moderate differentiation was higher than that with high differentiation(p<0.05).The Spearman correlation analysis showed that Prxs and NF-κB expression was negative correlation in VLS,and positive correlation in VSCC.Conclusion: The higher expression of Prxs and NF-κB proteins promotes VSCC development.The lower expression of NF-κB protein is associated with the occurrence of VLS.The higher expression of Prxs is associated with inhibiting the occurrence of VLS.